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Estimation of exposure to dietary acrylamide based on mercapturic acids level in urine of Polish women post partum and an assessment of health risk

Journal of Exposure Science & Environmental Epidemiology volume 26, pages 288–295 (2016)Cite this article

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Abstract

We determined metabolites of acrylamide and glycidamide concentrations (AAMA and GAMA, respectively) in urine of 93 women within the first days after delivery, using LC-MS/MS. The median AAMA and GAMA levels in urine were 20.9 μg/l (2.3÷399.0 μg/l) and 8.6 μg/l (1.3÷85.0 μg/l), respectively. In smokers we found significantly (P<0.01) higher levels of metabolites in comparison with the non-smoking women. As demonstrated by the 24-h dietary recall, acrylamide intake was low (median: 7.04 μg/day). Estimated exposure to acrylamide based on AAMA and GAMA levels in the whole group of women was 0.16 μg/kg b.w./day (1.15 μg/kg b.w./day, P95). We found significantly (P<0.05) higher exposure in women who consumed higher amount of acrylamide in the diet (≥10 μg/day vs <10 μg/day). A weak but significant positive correlation between acrylamide intake calculated on the basis of urinary levels of AAMA and GAMA and estimated on the basis of 24-h dietary recall (r=0.26, P<0.05) was found. The estimated margin of exposure values were below 10 000 and ranged from 156 for 95th percentile to 1938 for median acrylamide intake. Our results have shown that even a low dietary acrylamide intake may be associated with health risk.

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Acknowledgements

This project was supported by a grant from the Ministry of Science and Higher Education (No. N N404 067740). We thank Professor Jürger Angerer and Dr Birgit Schindler for providing the standards of GAMA and GAMA-d3 to start the research. We also thank Dr Iwona Sajór and Ms Sylwia Gugała-Mirosz for conducting the 24-h dietary recalls and Ms Irena Stolarska for the excellent urinary creatinine level analyses.

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Authors and Affiliations

  1. Department of Food and Food Supplements, National Food and Nutrition Institute, Warsaw, Poland

    Hanna Mojska & Iwona Gielecińska

  2. Clinic of Obstetrics, Gynaecology and Oncology, 2nd Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland

    Aleksandra Zielińska, Joanna Winiarek & Włodzimierz Sawicki

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  1. Hanna Mojska
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Correspondence to Hanna Mojska.

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Mojska, H., Gielecińska, I., Zielińska, A. et al. Estimation of exposure to dietary acrylamide based on mercapturic acids level in urine of Polish women post partum and an assessment of health risk. J Expo Sci Environ Epidemiol 26, 288–295 (2016). https://doi.org/10.1038/jes.2015.12

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