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Fetal heart rate and motor activity associations with maternal organochlorine levels: results of an exploratory study

Journal of Exposure Science & Environmental Epidemiology volume 24, pages 474–481 (2014)Cite this article

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Abstract

Contemporaneous associations between circulating maternal organochlorines (OCs) and measures of fetal heart rate and motor activity were evaluated. A panel of 47 OCs, including pesticides and polychlorinated biphenyls (PCBs), was analyzed from serum of 50 pregnant women at 36 weeks gestation. Data were empirically reduced into four factors and six individual compounds. All participants had detectable concentrations of at least one-quarter of the assayed OCs and, in general, higher socioeconomic level was associated with higher OC concentrations. Fetal heart rate measures were not consistently associated with maternal OCs. In contrast, one or more indicators of greater fetal motor activity were significantly associated with higher levels of the DDT and low chlorinated OC factors and five of the six individual compounds (heptachlor epoxide, trans nonachlor, oxychlordane, and PCBs 18 and 52). This preliminary demonstration of associations between fetal motor activity and maternal concentrations of persistent and pervasive environmental contaminants suggests that fetal assessment may be useful in ascertaining the potential early effects of these compounds on development.

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Acknowledgements

This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 2R01 HD27592, awarded to JA DiPietro and a pilot project funded by the National Institute of Environmental Health Sciences (NIEHS) Center grant ES03819.

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Authors and Affiliations

  1. Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

    Janet A DiPietro

  2. Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

    Meghan F Davis

  3. Division of Maternal-Fetal Medicine,

    Kathleen A Costigan

  4. Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

    Kathleen A Costigan

  5. Department of Environmental Health, Rollins School of Public Health, Atlanta, Georgia, USA

    Dana Boyd Barr

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  1. Janet A DiPietro
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Correspondence to Janet A DiPietro.

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DiPietro, J., Davis, M., Costigan, K. et al. Fetal heart rate and motor activity associations with maternal organochlorine levels: results of an exploratory study. J Expo Sci Environ Epidemiol 24, 474–481 (2014). https://doi.org/10.1038/jes.2013.19

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