Abstract
(+)-Antimycin A9 (AA9) isolated from a cultured broth of Streptomyces sp. K01-0031 was synthesized via an asymmetric aldol reaction using Oppolzer's sultam as a chiral auxiliary.
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When the aldol reaction of 2 and 3 was carried out under the original conditions, none of the desired compound was obtained.
The stereochemistry of the minor adduct was presumed to be 2S,3S.
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This is the first example of lactonization of pyridinethiol ester using (CuOTf)2·PhH.
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Nishii, T., Inai, M., Kaku, H. et al. A Practical Total Synthesis of (+)-Antimycin A9. J Antibiot 60, 65–72 (2007). https://doi.org/10.1038/ja.2007.9
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DOI: https://doi.org/10.1038/ja.2007.9
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