Abstract
Seven new related compounds named bispolides A1, A2, A3, B1, B2a, B2b and B3, have been found in a culture of Microbispora sp. A34030, isolated from a Malaysian soil sample. The planar structures were elucidated to be new 20-membered ring macrodiolide antibiotics on the basis of MS and NMR spectroscopic analyses. These antibiotics showed a good anti-MRSA activity in vitro.
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Okujo, N., Iinuma, H., George, A. et al. Bispolides, Novel 20-Membered Ring Macrodiolide Antibiotics from Microbispora. J Antibiot 60, 216–219 (2007). https://doi.org/10.1038/ja.2007.26
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DOI: https://doi.org/10.1038/ja.2007.26
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