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Oligomerization of Vibrio Cholerae Hemolysin Induces CXCR3 Upregulation and Activation of B-1a Cell

Cellular & Molecular Immunology volume 5, pages 231–234 (2008)Cite this article

Abstract

The hemolysin oligomer promotes the proliferation of B-1a cells and the expression of CD25, which is indicative of cell activation, on B-1a cells. The upregulation of CD86 induced by the oligomer showed its selective bias for the B7-2 member of B7 family while the monomer failed to induce these effects. The oligomer induced the expression of CXCR3, associated with B cell activation, while the monomer induced the expression of CXCL4, a powerful angiostatic chemokine. In conclusion, we found that B-1a cells responded to the apoptogenic monomer by expressing CXCL4, whereas oligomerization of the immunogen induced CXCR3 to shift the response towards activation.

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Authors and Affiliations

  1. Division of Immunology, National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road, Scheme XM, Kolkata, 700 010, West Bengal, India

    Gayatri Mukherjee & Tapas Biswas

  2. Division of Biochemistry, National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road, Scheme XM, Kolkata, 700 010, West Bengal, India

    Kalyan K Banerjee

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  1. Gayatri Mukherjee
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  2. Kalyan K Banerjee
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  3. Tapas Biswas
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Correspondence to Tapas Biswas.

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Mukherjee, G., Banerjee, K. & Biswas, T. Oligomerization of Vibrio Cholerae Hemolysin Induces CXCR3 Upregulation and Activation of B-1a Cell. Cell Mol Immunol 5, 231–234 (2008). https://doi.org/10.1038/cmi.2008.29

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  • DOI: https://doi.org/10.1038/cmi.2008.29

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