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Elevated pretransplant serum ferritin is associated with inferior survival following nonmyeloablative allogeneic transplantation

Bone Marrow Transplantation volume 44, pages 767–768 (2009)Cite this article

Iron overload is a well-established adverse prognostic factor for allogeneic hematopoietic SCT in thalassemia,1 and elevated pretransplant serum ferritin seems to adversely affect prognosis with myeloablative transplantation2, 3 for other diseases as well, primarily because of increased non-relapse mortality. We analyzed patients who underwent nonmyeloablative preparation for allogeneic transplantation to determine whether the presence of iron overload was also an adverse prognostic factor for patients undergoing nonmyeloablative transplants.

A total of 64 patients undergoing nonmyeloablative allogeneic transplantation for various disorders between 12/00 and 12/06 had pretransplant ferritin levels measured within 100 days preceding transplantation. Patient and transplant characteristics are summarized in Table 1. Median ferritin was 961 ng/ml (range, 30–6251 ng/ml).

Table 1 Patient and transplant characteristics
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References

  1. Lucarelli G, Clift RA, Galimberti M, Angelucci E, Giardini C, Baronciani D et al. Bone marrow transplantation in adult thalassemic patients. Blood 1999; 93: 1164–1167.

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Authors and Affiliations

  1. Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

    A Mahindra, R Sobecks, L Rybicki, B Pohlman, R Dean, S Andresen, M Kalaycio, J Sweetenham, B Bolwell & E Copelan

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  1. A Mahindra
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  2. R Sobecks
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  3. L Rybicki
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  4. B Pohlman
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  5. R Dean
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  6. S Andresen
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  7. M Kalaycio
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  8. J Sweetenham
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  9. B Bolwell
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  10. E Copelan
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Correspondence to A Mahindra.

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Mahindra, A., Sobecks, R., Rybicki, L. et al. Elevated pretransplant serum ferritin is associated with inferior survival following nonmyeloablative allogeneic transplantation. Bone Marrow Transplant 44, 767–768 (2009). https://doi.org/10.1038/bmt.2009.77

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