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Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: Influence of H1 and H2 histamine receptors

British Journal of Cancer volume 45, pages 54–60 (1982)Cite this article

Abstract

C3H and C57 BL/6 mice carrying methylcholanthrene-induced fibrosarcomas were injected i.p. daily with histamine, metiamide (anti-histamine type-2 receptor), histamine + metiamide, mepyramine (anti-histamine type-1 receptor), serotonin and methysergide (anti-serotonin). Inhibition of tumour growth and lengthened survival were observed with histamine and histamine + metiamide. The best results (both on tumour growth and survival) were obtained with serotonin. Survival was increased by metiamide and decreased by mepyramine and methysergide. In histamine-treated and in serotonin-treated mice, histological studies of the tumours showed large and numerous foci of haemorrhagic necrosis. Stimulation of histamine type-1 or serotonin receptors and inhibition of histamine type-2 receptors play a beneficial role in the host's defence against tumours.

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Authors
  1. C Burtin
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  2. P Scheinmann
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  3. J C Salomon
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  4. G Lespinats
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  5. P Canu
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Burtin, C., Scheinmann, P., Salomon, J. et al. Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: Influence of H1 and H2 histamine receptors. Br J Cancer 45, 54–60 (1982). https://doi.org/10.1038/bjc.1982.7

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  • DOI: https://doi.org/10.1038/bjc.1982.7

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