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Where cancer meets calcium — p53 crosstalk with EF-hands

Nature Structural Biology volume 7, pages 525–527 (2000)Cite this article

S100B, an EF-hand Ca2+-binding protein, grasps the C-terminus of the tumor suppressor p53 and inhibits protein kinase C-dependent phosphorylation and acetylation of p53 in a Ca2+-dependent manner. The mode of interaction between S100B and p53 is different from the interactions seen in S100A–annexin complex structures.

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Figure 1: A proposed action of S100B in p53 function.
Figure 2: Solved structures of p53 domains alone and in complex with interacting proteins.
Figure 3: Structures of S100–target peptide complexes.

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Authors and Affiliations

  1. the Division of Molecular and Structural Biology, Ontario Cancer Institute and the Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, M5G 2M9, Ontario, Canada

    Mitsuhiko Ikura & Kyoko L. Yap

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  1. Mitsuhiko Ikura
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  2. Kyoko L. Yap
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Correspondence to Mitsuhiko Ikura.

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Ikura, M., Yap, K. Where cancer meets calcium — p53 crosstalk with EF-hands. Nat Struct Mol Biol 7, 525–527 (2000). https://doi.org/10.1038/76721

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