A protein called small ubiquitin-related modifier (SUMO) can be coupled to other proteins to control their function. This SUMOylation has been implicated in the regulation of a host of cellular processes, and is essential for the health, and even the survival, of most organisms.
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Meulmeester, E., Melchior, F. SUMO. Nature 452, 709–711 (2008). https://doi.org/10.1038/452709a
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DOI: https://doi.org/10.1038/452709a