Many cellular functions are carried out by proteins that are bound together in complexes. In two new large-scale studies, labelled proteins are used as 'bait' to capture and identify those complexes.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Methylated-antibody affinity purification to improve proteomic identification of plant RNA polymerase Pol V complex and the interacting proteins
Scientific Reports Open Access 22 February 2017
-
Improved method for protein complex detection using bottleneck proteins
BMC Medical Informatics and Decision Making Open Access 05 April 2013
-
PCDq: human protein complex database with quality index which summarizes different levels of evidences of protein complexes predicted from H-Invitational protein-protein interactions integrative dataset
BMC Systems Biology Open Access 12 December 2012
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gavin, A.-C. et al. Nature 415, 141–147 (2002).
Ho, Y. et al. Nature 415, 180–183 (2002).
Uetz, P. et al. Nature 403, 623–627 (2000).
Ito, T. et al. Proc. Natl Acad. Sci. USA 98, 4569–4574 (2001).
Zhu, H. et al. Science 293, 2101–2105 (2001).
Gelperin, D. et al. Proc. Natl Acad. Sci. USA 92, 11539–11543 (1995).
Roberts, R. L. et al. Cell 89, 1055–1065 (1997).
Beck, T. & Hall, M. N. Nature 402, 689–692 (1999).
Guzder, S. N., Sung, P., Prakash, L. & Prakash, S. J. Biol. Chem. 273, 31541–31546 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kumar, A., Snyder, M. Protein complexes take the bait. Nature 415, 123–124 (2002). https://doi.org/10.1038/415123a
Issue Date:
DOI: https://doi.org/10.1038/415123a
This article is cited by
-
Identifying spreading influence nodes for social networks
Frontiers of Engineering Management (2022)
-
Protein interaction networks: centrality, modularity, dynamics, and applications
Frontiers of Computer Science (2021)
-
A survey of computational methods in protein–protein interaction networks
Annals of Operations Research (2019)
-
Methylated-antibody affinity purification to improve proteomic identification of plant RNA polymerase Pol V complex and the interacting proteins
Scientific Reports (2017)
-
Improved method for protein complex detection using bottleneck proteins
BMC Medical Informatics and Decision Making (2013)