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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

Nature volume 384, pages 134–141 (1996)Cite this article

Abstract

Recognition by a T-cell antigen receptor (TCP) of peptide complexed with a major histo-compatibility complex (MHC) molecule occurs through variable loops in the TCP structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCP fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.

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Authors and Affiliations

  1. Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachussetts, 02138, USA

    David N. Garboczi, Partho Ghosh, Qing R. Fan & Don C. Wiley

  2. Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachussetts, 02138, USA

    Don C. Wiley

  3. Laboratoire d'lmmunologie, Institut de Recherches Cliniques de Montreal, 110 Avenue des Pins Quest, Montreal, H2W 1R7, Canada

    Ursula Utz

  4. Molecular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA

    William E. Biddison

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  1. David N. Garboczi
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  4. Qing R. Fan
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  6. Don C. Wiley
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Garboczi, D., Ghosh, P., Utz, U. et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384, 134–141 (1996). https://doi.org/10.1038/384134a0

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