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Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1

Nature volume 379, pages 826–829 (1996)Cite this article

Abstract

THE process of learning involves stable changes in synaptic efficacy for which long-term potentiation (LTP)1 provides a widely adopted mammalian model. Synaptic modification induced by learning or LTP may involve the action of cell adhesion molecules2–4. One such candidate is the ubiquitous neuronal glycoprotein Thy-1 (refs 5, 6). In mice in which the gene encoding Thy-1 has been inactivated, we find a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus. Spatial learning by Thy-1-deficient mice, as assessed in the watermaze7, is unimpaired. Thus LTP in the cortical input to the dentate gyrus seems not to be required for spatial learning.

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Author notes

  1. M. Nosten-Bertrand

    Present address: UMB C9923 au CNRS, Hôpital de la Pitié Salpêtrière, 75013, Paris, France

Authors and Affiliations

  1. Department of Neurobiology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    M. Nosten-Bertrand, E. Barboni, E. Kozlova & R. J. Morris

  2. Department of Neurophysiology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    M. L. Errington, K. P. S. J. Murphy & T. V. P. Bliss

  3. Division of Molecular Medicine, North Shore University Hospital, Cornell University Medical College, New York, 11030, USA

    Y. Tokugawa & J. Silver

  4. Department of Human Biopathology, University of Rome 'La Sapienza', Rome, 00100, Italy

    E. Barboni

  5. Department of Cell Biology and Genetics, Erasmus University, Rotterdam, 3000DR, The Netherlands

    D. Michalovich

  6. Centre for Neuroscience, University of Edinburgh, Edinburgh, EH8 9LE, UK

    R. G. M. Morris

  7. Roche Institute of Molecular Biology, Nutley, New Jersey, 07110, USA

    C. L. Stewart

  8. Department of Experimental Pathology, UMDS Guy's Hospital, London Bridge, London, SE1 9RT, UK

    R. J. Morris

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Nosten-Bertrand, M., Errington, M., Murphy, K. et al. Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature 379, 826–829 (1996). https://doi.org/10.1038/379826a0

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