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Fasciclin III as a synaptic target recognition molecule in Drosophila

Nature volume 374, pages 166–168 (1995)Cite this article

Abstract

FASCICLIN III, a cell adhesion molecule of the immunoglobulin superfamily1–3, is expressed by motor neuron RP3 and its synaptic targets (muscle cells 6 and 7) during embryonic neuromuscular development of Drosophila4. We report here that RP3 often incorrectly innervates neighbouring non-target muscle cells when these cells misexpress fasciclin III, but still innervates normal targets in the fasciclin III null mutant. Fasciclin III manipulations do not influence target selections by other motor neurons, including fasciclin Ill-expressing RP1. We propose that fasciclin III acts as a synaptic target recognition molecule for motor neuron RP3, and also that its absence can be compensated for by other molecule(s).

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Author notes

  1. Akira Chiba

    Present address: Department of Cell and Structural Biololgy, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA

Authors and Affiliations

  1. Department of Physics, University of Tokyo, Graduate School of Science, Tokyo, 113, Japan

    Akira Chiba & Yoshik Hotta

  2. National Institute for Basic Biology, Laboratory of Cellular Communication, Okazaki, 444, Japan

    Akira Chiba & Yoshik Hotta

  3. Department of Biological Sciences, State University of New York, Albany, New York, 12222, USA

    Peter Snow

  4. Department of Biology, Yale University, New Haven, Connecticut, 06520-8103, USA

    Haig Keshishian

Authors
  1. Akira Chiba
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  2. Peter Snow
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  3. Haig Keshishian
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  4. Yoshik Hotta
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Chiba, A., Snow, P., Keshishian, H. et al. Fasciclin III as a synaptic target recognition molecule in Drosophila. Nature 374, 166–168 (1995). https://doi.org/10.1038/374166a0

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  • DOI: https://doi.org/10.1038/374166a0

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