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The ancient regulatory-protein family of WD-repeat proteins

Nature volume 371, pages 297–300 (1994)Cite this article

An Erratum to this article was published on 27 October 1994

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.

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Authors and Affiliations

  1. the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School,

    Eva J. Neer & Carl J. Schmidt

  2. the Department of Pharmacology and Biomolecular Engineering Research Centre, Boston University, Boston, Massachusetts, 02215, USA

    Raman Nambudripad & Temple F. Smith

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  1. Eva J. Neer
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  4. Temple F. Smith
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Neer, E., Schmidt, C., Nambudripad, R. et al. The ancient regulatory-protein family of WD-repeat proteins. Nature 371, 297–300 (1994). https://doi.org/10.1038/371297a0

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