Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

Abstract

DURING biosynthesis, class II molecules of the major histo-compatibility complex are associated with a nonpolymorphic protein called invariant chain, li, which facilitates folding of class II molecules and their exit from the endoplasmic reticulum1–4, interferes with their association with peptide5,6 and directs their post-Golgi transport (refs 7–9). If li blocks class II loading with endogenous antigens in the endoplasmic reticulum and/or directs class II molecules to the exogenous antigen-loading compartment, then the co-expression of li should enhance the ability of class II molecules to present exogenous antigens to T cells. But data supporting a role for li in class II-restricted antigen presentation are controversial1,10–13. Here we show that Ii can facilitate exogenous antigen presentation for a subset of antigens. Although all known functions of Ii have been ascribed to the principal form of Ii, p31, we find that in most cases antigen presentation is facilitated only by the alternatively spliced, minor form of Ii, p41.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Peterson, M. & Miller, J. Nature 345, 172–174 (1990).

    Article  ADS  CAS  Google Scholar 

  2. Layet, C. & Germain, R. Proc. natn. Acad. Sci. U.S.A. 88, 2346–2350 (1991).

    Article  ADS  CAS  Google Scholar 

  3. Schaiff, W., Hruska, K., Bono, C., Shuman, S. & Schwartz, B. J. Immun. 147, 603–608 (1991).

    CAS  PubMed  Google Scholar 

  4. Anderson, M. & Miller, J. Proc. natn. Acad. Sci. U.S.A. 89, 2282–2286 (1992).

    Article  ADS  CAS  Google Scholar 

  5. Roche, P. & Cresswell, P. Nature 345, 615–618 (1990).

    Article  ADS  CAS  Google Scholar 

  6. Teyton, L. et al. 348, 39–44 (1990).

  7. Bakke, O. & Dobberstein, B. Cell 63, 707–716 (1990).

    Article  CAS  Google Scholar 

  8. Lotteau, V. et al. Nature 348, 600–605 (1990).

    Article  ADS  CAS  Google Scholar 

  9. Lamb, C., Yewdell, J., Bennink, J. & Cresswell, P. Proc. natn. Acad. Sci. U.S.A. 88, 5998–6002 (1991).

    Article  ADS  CAS  Google Scholar 

  10. Sekaly, R. et al. Proc. natn. Acad. Sci. USA. 85, 1209–1213 (1988).

    Article  ADS  CAS  Google Scholar 

  11. Stockinger, B. et al. Cell 56, 683–689 (1989).

    Article  CAS  Google Scholar 

  12. Bertolino, P. et al. Int. Immun. 3, 435–443 (1991).

    Article  CAS  Google Scholar 

  13. Nadimi, F. et al. Eur. J. Immun. 21, 1255–1263 (1991).

    Article  CAS  Google Scholar 

  14. Yamamoto, K., Koch, N., Steinmetz, M. & Hammerling, G. J. Immun. 134, 3461–3476 (1985).

    CAS  PubMed  Google Scholar 

  15. Koch, N., Lamer, W., Habicht, J. & Dobberstein, B. EMBO J. 6, 1677–1683 (1987).

    Article  CAS  Google Scholar 

  16. Miller, J., Hatch, J., Simonis, S. & Cullen, S. Proc. natn. Acad. Sci. U.S.A. 85, 1369–1363 (1988).

    Article  ADS  Google Scholar 

  17. Ekholm, R. Int. Rev. Cytol. 120, 243–288 (1990).

    Article  CAS  Google Scholar 

  18. Harding, C., Roof, R., Allen, P. & Unanue, E. Proc. natn. Acad. Sci. U.S.A. 88, 2740–2744 (1991).

    Article  ADS  CAS  Google Scholar 

  19. Jensen, P. J. exp. Med. 171, 1779–1784 (1990).

    Article  CAS  Google Scholar 

  20. Pieters, J., Horstmann, H., Bakke, O., Griffiths, G. & Lipp, J. J. Cell Biol. 115, 1213–1223 (1991).

    Article  CAS  Google Scholar 

  21. Peters, P., Neefjes, J., Oorschot, V., Ploegh, H. & Geuze, H. Nature 349, 669–676 (1991).

    Article  ADS  CAS  Google Scholar 

  22. Roche, P., Marks, M. & Cresswell, P. Nature 354, 392–394 (1991).

    Article  ADS  CAS  Google Scholar 

  23. Shimonkevitz, R., Kappler J., Marrack, P. & Grey, H. J. exp. Med. 158, 303–316 (1983).

    Article  CAS  Google Scholar 

  24. Shimonkevitz, R., Colon, S., Kapplar, J., Marrack, P. & Grey, H. J. Immun. 133, 2067– (1984).

    CAS  PubMed  Google Scholar 

  25. Jensen, P. J. Immun. 141, 2545–2550 (1988).

    CAS  PubMed  Google Scholar 

  26. Rosioniec, E. et al. J. Immun. 143, 50–58 (1989).

    Google Scholar 

  27. Lorenz, R., Tyler, A. & Allen, P. J. Immun. 141, 4124–4128 (1988).

    CAS  PubMed  Google Scholar 

  28. Allen, P., Strydom, D. & Unanue, E. Proc. natn. Acad. Sci. U.S.A. 81, 2489–2493 (1984).

    Article  ADS  CAS  Google Scholar 

  29. Haskins, K. et al. J. exp. Med. 160, 452–471 (1984).

    Article  CAS  Google Scholar 

  30. Ozaki, S., Duram, S., Muegge, K., York-Jolley, J. & Berzofsky, J. J. Immun. 141, 71–78 (1988).

    CAS  PubMed  Google Scholar 

  31. Kappler, J., White, J., Wegmann, D., Mustain, E. & Marrack, P. Proc. natn. Acad. Sci. U.S.A. 79, 3604–3608 (1982).

    Article  ADS  CAS  Google Scholar 

  32. Blum, J. & Cresswell, P. Proc. natn. Acad. Sci. U.S.A. 85, 3975–3979 (1988).

    Article  ADS  CAS  Google Scholar 

  33. Braunstein, N., Germain, R., Loney, K. & Berkowitz, N. J. Immun. 145, 1635–1645 (1990).

    CAS  Google Scholar 

  34. Pierres, M., Devaux, C., Dosseto, M. & Marchetto, S. Immunogenetics 14, 481–495 (1981).

    Article  CAS  Google Scholar 

  35. Sette, A. et al. J. Immun. 148, 844–851 (1992).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Peterson, M., Miller, J. Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41. Nature 357, 596–598 (1992). https://doi.org/10.1038/357596a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/357596a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing