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Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

Nature volume 351, pages 535–541 (1991)Cite this article

Abstract

Developmental, genetic and molecular studies indicate that multiple intercellular signalling systems interact to specify the types and spatial patterns of cells generated during the formation of the vulva of the nematode Caenorhabditis elegans. Two classes of evolutionary conserved transmembrane receptors and a Ras protein function in these signalling systems. The biology of vulval development provides a framework for understanding how cell interactions control the development of animals as diverse as nematodes, insects and mammals.

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Authors and Affiliations

  1. Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139, USA

    H. Robert Horvitz

  2. Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, 91125, USA

    Paul W. Sternberg

Authors
  1. H. Robert Horvitz
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  2. Paul W. Sternberg
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Horvitz, H., Sternberg, P. Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva. Nature 351, 535–541 (1991). https://doi.org/10.1038/351535a0

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