Nature 351, 290 - 296 (23 May 1991); doi:10.1038/351290a0

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

Kirsten Falk, Olaf Rötzschke, Stefan Stevanovié^*, Günther Jung^* & Hans-Georg Rammensee^†

Max-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, W-7400 Tübingen, Germany
^* Institut für Organische Chemie, Universität Tübingen, Auf der Morgenstelle 18, W-7400 Tübingen, Germany
^† To whom correspondence should be addressed. 290

The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information about the contents of MHC grooves is now provided. Moreover, each MHC class I allele has its individual rules to which peptides presented in the groove adhere.

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