Review
Nature Reviews Cancer 1, 222-231 (December 2001) | doi:10.1038/35106065
Milestones in cell division : To cycle or not to cycle: a critical decision in cancer
Marcos Malumbres1 & Mariano Barbacid About the authors
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Abstract
Tumour cells undergo uncontrolled proliferation, yet tumours most often originate from adult tissues, in which most cells are quiescent. So, the proliferative advantage of tumour cells arises from their ability to bypass quiescence. This can be due to increased mitogenic signalling and/or alterations that lower the threshold required for cell-cycle commitment. Understanding the molecular mechanisms that underlie this commitment should provide important insights into how normal cells become tumorigenic and how new anticancer strategies can be devised.
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Author affiliations
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Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas,
Melchor Fernández Almagro 3, E-28029 Madrid, and Centro Nacional de
Biotecnología, CSIC, Campus de Cantoblanco, E-28049 Madrid, Spain.
emails: Email: marcos.malumbres@cnio.es, Email: mariano.barbacid@cnio.es