Review
Nature Reviews Cancer 1, 181-193 (December 2001) | doi:10.1038/35106036
The promise of retinoids to fight against cancer
Lucia Altucci1,2 & Hinrich Gronemeyer2 About the authors
Top of page
Abstract
Retinoids have a reputation for being both detrimental and beneficial: they are teratogens, but they also have tumour-suppressive capacity. Cell biology and genetics have significantly improved our understanding of the mechanisms that underlie the anti-proliferative action of retinoids. Recent elucidation of the pathways that are activated by retinoids will help us to exploit the beneficial aspects of this powerful class of compounds for cancer therapy and prevention.
- View At a Glance
Author affiliations
-
Dipartimento di Patologia Generale e Oncologia, Seconda Università degli Studi di Napoli, via L. de Crecchio, Napoli 80138, Italy.
Email: lucia.altucci@unina2.it -
Institut de Génétique et de Biologie Moléculaire et Cellulaire, (IGBMC)/CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C. U. de Strasbourg, France.
Email: hg@igbmc.u-strasbg.fr