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Structure and function of telomeres

Abstract

The DNA of telomeres—the terminal DNA-protein complexes of chromosomes—differs notably from other DNA sequences in both structure and function. Recent work has highlighted its remarkable mode of synthesis by the ribonucleoprotein reverse transcriptase, telomerase1–4, as well as its ability to form unusual structures in vitro. Moreover, telomere synthesis by telomerase has been shown to be essential for telomere maintenance and long-term viability.

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References

  1. Blackburn, E. H. & Szostak, J. W. A. Rev. Biochem. 53, 163–194 (1984).

    Article  CAS  Google Scholar 

  2. Zakian, V. A. A. Rev. Genet. 23, 579–604 (1989).

    Article  CAS  Google Scholar 

  3. Blackburn, E. H. Science 249, 489–490 (1990).

    Article  ADS  CAS  Google Scholar 

  4. Murray, A. W. & Szostak, J. W. Nature 305, 189–193 (1983).

    Article  ADS  CAS  Google Scholar 

  5. Brown, W. R. A. et al. Cell 63, 119–132 (1990).

    Article  CAS  Google Scholar 

  6. Klobutcher, L. A., Swanton, M. T., Donini, P. & Prescott, D. M. Proc. natn. Acad. Sci. U.S.A. 78, 3015–3019 (1981).

    Article  ADS  CAS  Google Scholar 

  7. Henderson, E. R. & Blackburn, E. H. Molec. cell. Biol. 9, 345–348 (1989).

    Article  CAS  Google Scholar 

  8. Greider, C. W. & Blackburn, E. H. Nature 337, 331–337 (1989).

    Article  ADS  CAS  Google Scholar 

  9. Shippen-Lentz, D. & Blackburn, E. H. Science 247, 546–552 (1990).

    Article  ADS  CAS  Google Scholar 

  10. Greider, C. W. & Blackburn, E. H. Cell 43, 405–413 (1985).

    Article  CAS  Google Scholar 

  11. Greider, C. W. & Blackburn, E. H. Cell 51, 887–898 (1987).

    Article  CAS  Google Scholar 

  12. Zahler, A. M. & Prescott, D. M. Nucleic Acids Res. 16, 6953–6972 (1988).

    Article  CAS  Google Scholar 

  13. Shippen-Lentz, D. & Blackburn, E. H. Molec. cell. Biol. 9, 2761–2764 (1989).

    Article  CAS  Google Scholar 

  14. Morin, G. B. Cell 59, 521–529 (1989).

    Article  CAS  Google Scholar 

  15. Blackburn, E. H. et al. Genome 31, 553–560 (1989).

    Article  CAS  Google Scholar 

  16. Yu, G.-L., Bradley, J. D., Attardi, L. D. & Blackburn, E. H. Nature 344, 126–132 (1990).

    Article  ADS  CAS  Google Scholar 

  17. Lundblad, V. & Szostak, J. W. Cell 57, 633–643 (1989).

    Article  CAS  Google Scholar 

  18. Lundblad, V. & Blackburn, E. H. Cell 60, 529–530 (1990).

    Article  CAS  Google Scholar 

  19. Matsumoto, T. et al. Molec. cell. Biol. 7, 4424–4430 (1987).

    Article  CAS  Google Scholar 

  20. Kamper, J., Meinhardt, F., Gunge, N. & Esser, K. Molec. cell. Biol. 9, 3931–3937 (1989).

    Article  CAS  Google Scholar 

  21. Pologe, L. G. & Ravetch, J. N. Cell 55, 869–874 (1988).

    Article  CAS  Google Scholar 

  22. Gilley, D., Preer, J. R., Aufterheide, K. J. & Polisky, B. Molec. cell. Biol. 8, 4765–4772 (1988).

    Article  CAS  Google Scholar 

  23. Wilkie, A. M., Lamb, J., Harris, P. C. Finney, R. D. & Higgs, D. R. Nature 346, 868–871 (1990).

    Article  ADS  CAS  Google Scholar 

  24. Dunn, B., Szauter, P., Pardue, M. L. & Szostak, J. W. Cell 39, 191–201 (1984).

    Article  CAS  Google Scholar 

  25. Horowitz, H. & Haber, J. E. Molec. cell. Biol. 5, 2369–2380 (1985).

    Article  CAS  Google Scholar 

  26. Haber, J. E. & Thorburn, P. C. Genetics 106, 207–226 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Jger, D. & Philipsen, P. EMB0 J. 8, 247–254 (1989).

    Article  Google Scholar 

  28. Murray, A. W., Claus, T. & Szostak, J. W. Molec. cell. Biol. 8, 4642–4650 (1988).

    Article  CAS  Google Scholar 

  29. Walmsley, R. W., Chan, C. S. M., Tye, B. K. & Petes, T. D. Nature 310, 157–160 (1984).

    Article  ADS  CAS  Google Scholar 

  30. Pluta, A. F. & Zakian, V. A. Nature 337, 429–433 (1989).

    Article  ADS  CAS  Google Scholar 

  31. Wang, S.-S. & Zakian, V. A. Nature 345, 456–458 (1990).

    Article  ADS  CAS  Google Scholar 

  32. Gottschling, D. E. & Zakian, V. A. Cell 47, 195–205 (1986).

    Article  CAS  Google Scholar 

  33. Price, C. R. Molec. cell. Biol. 10, 3421–3431 (1990).

    Article  CAS  Google Scholar 

  34. Lustig, A. J., Kurtz, S. & Shore, D. 250, 549–552 (1990).

  35. Conrad, M. N., Wright, J. H., Wolf, A. J. & Zakian, V. A. Cell 63, 739–750 (1990).

    Article  CAS  Google Scholar 

  36. Price, C. M. & Cech, T. R. Biochemistry 28, 769–774 (1989).

    Article  CAS  Google Scholar 

  37. Hicke, B. J., Celander, D. W., MacDonald, G. R., Price, C. M. & Cech, T. R. Proc. natn. Acad. Sci. U.S.A. 87, 1481–1485 (1990).

    Article  ADS  CAS  Google Scholar 

  38. Raghuraman, M. K., Dunn, C. J., Hicke, B. J. & Cech, T. R. Nucleic Acids Res. 17, 4235–4253 (1989).

    Article  CAS  Google Scholar 

  39. Raghuraman, M. K. & Cech, T. R. Nucleic Acids Res. 18, 4543–4552 (1990).

    Article  CAS  Google Scholar 

  40. Berman, J., Tachibana, C. Y. & Tye, B.-K. Proc. natn. Acad. Sci. U.S.A. 83, 3713–3717 (1986).

    Article  ADS  CAS  Google Scholar 

  41. Buchman, A. R., Lue, N. F. & Kornberg, R. D. Molec. cell. Biol. 8, 210–255 (1988).

    Article  CAS  Google Scholar 

  42. Szostak, J. W. & Blackburn, E. H. Cell 29, 245–255 (1982).

    Article  CAS  Google Scholar 

  43. Shampay, J., Szostak, J. W. & Blackburn, E. H. Nature 310, 154–157 (1984).

    Article  ADS  CAS  Google Scholar 

  44. Riethman, H. C., Moyzis, R. K., Meyne, J., Burke, D. T. & Olson, M. V. Proc. natn. Acad. Sci. U.S.A. 86, 6240–6244 (1989).

    Article  ADS  CAS  Google Scholar 

  45. Gottschling, D. E., Aparicio, O. M., Billington, B. L. & Zakian, V. A. Cell 63, (1990).

    Article  CAS  Google Scholar 

  46. Henderson, E. et al. Cancer Cells 6, 453–461 (eds Kelly, T. & Stillman, B.) (Cold Spring Harbor Laboratory, New York, 1988).

    Google Scholar 

  47. Budarf, M. & Blackburn, E. H. Nucleic Acids Res. 15, 6273–6292 (1987).

    Article  CAS  Google Scholar 

  48. Frank-Kamenetskii, M. Nature 342, 737 (1989).

    Article  ADS  CAS  Google Scholar 

  49. Usdin, K. & Furano, A. Proc. natn. Acad. Sci. U.S.A. 85, 4416–4420 (1988).

    Article  ADS  CAS  Google Scholar 

  50. Henderson, E., Hardin, C. C., Wolk, S. K., Tinoco, I. & Blackburn, E. H. Cell 51, 899–908 (1987).

    Article  CAS  Google Scholar 

  51. Hardin, C. C., Henderson, E. R., Watson, T. & Prosser, J. Biochemistry (in the press).

  52. Henderson, E. R., Moore, M. & Malcolm, B. A. Biochemistry 29, 732–737 (1990).

    Article  CAS  Google Scholar 

  53. Sen, D. & Gilbert, W. Nature 344, 410–414 (1990).

    Article  ADS  CAS  Google Scholar 

  54. Sundquist, W. I. & Klug, A. Nature 342, 825–829 (1989).

    Article  ADS  CAS  Google Scholar 

  55. Williamson, J. R., Raghuraman, M. K. & Cech, T. R. Cell 59, 871–880 (1990).

    Article  Google Scholar 

  56. Sundquist, W. I. in Nucleic Acids and Molecular Biology (eds Lilley, D. M. J. & Eckstein, F.) Vol. 5 (Springer, in the press).

  57. Shampay, J. & Blackburn, E. H. Proc. natn. Acad. Sci. U.S.A. 85, 534–538 (1988).

    Article  ADS  CAS  Google Scholar 

  58. Bernards, A., Michels, P. A. M., Lincke, C. R. & Borst, P. Nature 303, 592–597 (1983).

    Article  ADS  CAS  Google Scholar 

  59. Walmsley, R. M. & Petes, T. D. Proc. natn. Acad. Sci. U.S.A. 82, 506–510 (1985).

    Article  ADS  CAS  Google Scholar 

  60. Lustig, A. J. & Petes, T. D. Proc. natn. Acad. Sci. U.S.A. 83, 1398–1402 (1986).

    Article  ADS  CAS  Google Scholar 

  61. Larson, D. D., Spangler, E. A. & Blackburn, E. H. Cell 50, 477–483 (1987).

    Article  CAS  Google Scholar 

  62. Runge, K. W. & Zakian, V. A. Molec. cell. Biol. 9, 1488–1497 (1989).

    Article  CAS  Google Scholar 

  63. Levis, R. W. Cell 58, 791–801 (1989).

    Article  CAS  Google Scholar 

  64. Biessmann, H., Carter, S. B. & Mason, J. M. Proc. natn. Acad. Sci. U.S.A. 87, 1758–1761 (1990).

    Article  ADS  CAS  Google Scholar 

  65. Moyzis, R. K. et al. Proc. natn. Acad. Sci. U.S.A. 85, 6622–6626 (1988).

    Article  ADS  CAS  Google Scholar 

  66. Cooke, H. J. & Smith, B. A. Cold Spring Harb. Symp. quant. Biol. 51, 213–219 (1986).

    Article  CAS  Google Scholar 

  67. Harley, C. B., Futcher, A. B. & Greider, C. W. Nature 345, 458–460 (1990).

    Article  ADS  CAS  Google Scholar 

  68. Hastie, N. D. et al. Nature 346, 866–868 (1990).

    Article  ADS  CAS  Google Scholar 

  69. Olovnikov, A. M. J. theor. Biol. 41, 181–190 (1973).

    Article  CAS  Google Scholar 

  70. Kipling, D. & Cooke, H. J. Nature 347, 400–402 (1990).

    Article  ADS  CAS  Google Scholar 

  71. Gottschling, D. E. & Cech, T. R. Cell 38, 501–510 (1984).

    Article  CAS  Google Scholar 

  72. Budarf, M. & Blackburn, E. H. J. biol. Chem. 261, (1986).

  73. Zahler, A. M. & Prescott, D. M. Nucleic Acid Res. 17, 6299–6317 (1989).

    Article  CAS  Google Scholar 

  74. Zahler, A. M., Williamson, J. R., Cech, T. R. & Prescott, D. M. Nature (in the press).

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Blackburn, E. Structure and function of telomeres. Nature 350, 569–573 (1991). https://doi.org/10.1038/350569a0

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