Brief Communications
Nature 409, 684 (8 February 2001) | doi:10.1038/35055628
Gene expression: View of a mouse clock gene ticking
Shun Yamaguchi1, Masaki Kobayashi2, Shigeru Mitsui1, Yoshiki Ishida1, Gijsbertus T. J. van der Horst3, Misao Suzuki4, Shigenobu Shibata5 & Hitoshi Okamura1
Circadian clocks consist of an ingenious autoregulatory feedback loop whereby the cyclically expressed products of the clock gene are able to inhibit their own expression<1. Here we follow the rhythmic expression of the clock gene mPer1 in the brain of a living mouse. This model system enables real-time gene expression to be monitored in the intact brain under physiological conditions.
- Department of Anatomy and Brain Science, Kobe University School of Medicine, Kobe 650-0017, Japan
- Department of Electronics, Tohoku Institute of Technology, Sendai 982-8577, Japan
- MGC, Department of Cell Biology and Genetics, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands
- Institute of Molecular Embryology and Genetics, Center for Animal Resources and Development, Kumamoto University School of Medicine, Kumamoto 862-0976, Japan
- Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa 359-1192, Japan
Correspondence to: Hitoshi Okamura1 e-mail: Email: okamurah@kobe-u.ac.jp