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Cloning of the T gene required in mesoderm formation in the mouse

Nature volume 343, pages 617–622 (1990)Cite this article

Abstract

The murine developmental mutation T identifies an essential gene in mesoderm formation. Embryos lacking normal gene activity fail to form the notochord, the entire posterior region and the allan-tois, and die at about 10 days of gestation. We have isolated the T gene using a combination of molecular and genetic techniques, thus making molecular tools available to study processes underlying mesoderm formation in the mouse.

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Author information

Author notes

  1. Bernhard G. Herrmann

    Present address: Max Planck-lnstitut für Entwicklungsbiologie, Spemannstrasse 35/II, 7400, Tübingen, FRG

  2. Thomas R. King

    Present address: The Jackson Laboratory, Bar Harbor, Maine, 04609, USA

Authors and Affiliations

  1. Laboratory of Molecular Embryology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Bernhard G. Herrmann

  2. European Molecular Biology Laboratory, Meyerhofstrasse 1, 6900, Heidelberg, FRG

    Siegfried Labeit

  3. German Cancer Research Center, Im Neuenheimer Feld 280, 6900, Heidelberg, FRG

    Annemarie Poustka

  4. Laboratory of Genetics and McArdle laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin, 53706, USA

    Thomas R. King

  5. Imperial Cancer Research Fund Laboratory, Lincoln's Inn Fields, PO Box No. 123, London, WC2A 3PX, UK

    Hans Lehrach

Authors
  1. Bernhard G. Herrmann
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  2. Siegfried Labeit
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  3. Annemarie Poustka
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  4. Thomas R. King
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  5. Hans Lehrach
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Herrmann, B., Labeit, S., Poustka, A. et al. Cloning of the T gene required in mesoderm formation in the mouse. Nature 343, 617–622 (1990). https://doi.org/10.1038/343617a0

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  • DOI: https://doi.org/10.1038/343617a0

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