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Incubation periods for paediatric AIDS patients

Nature volume 336, pages 575–577 (1988)Cite this article

Abstract

A recent seroprevalence study of newborns indicates that one in 62 children born in New York City has antibodies to the human immunodeficiency virus (HIV)1. The distribution of incubation periods for paediatric patients is needed to estimate future AIDS case loads from these seroprevalence data. Current estimates of incubation periods for paediatric patients are based on limited data2–5. We use parametric5,6 and non-parametric7,8 methods to analyse incubation periods for 215 paediatric patients with AIDS whose only known route of infection is maternal. We conclude that incubation periods are longer than previously reported9; that there is a distinct knee in the incubation period distribution at seven months which suggests two risk populations; and that there is an increase in incidence which is consistent with exponential growth.

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References

  1. Aids in New York State (New York State Department of Health, 1988).

  2. Medley, G. F., Anderson, R. M., Cox, D. R. & Billard, L. Nature 328, 719–721 (1987).

    Article  ADS  CAS  Google Scholar 

  3. Medley, G. F., Billard, L., Cox, D. R. & Anderson, R. M. Proc. R. Soc. Lond. B 233, 367–377 (1988).

    ADS  CAS  PubMed  Google Scholar 

  4. Kalbfleisch, J. D. & Lawless, J. F. Nature 333, 504–505 (1988).

    Article  ADS  CAS  Google Scholar 

  5. Lui, K., Peterman, T. A., Lawrence, D. N. & Allen, J. M. Statistics in Medicine 7, 395–401 (1988).

    Article  CAS  Google Scholar 

  6. Lui, K. et al. Proc. natn. Acad. Sci. U.S.A. 83, 3051–3055 (1986).

    Article  ADS  CAS  Google Scholar 

  7. Lagakos, S., Barraj, L. M. & De Gruttola, V. Biometrika 75, 515–523 (1988).

    Article  MathSciNet  Google Scholar 

  8. Turnbull, B. W. J. R. Statist. Soc. B 83, 290–295 (1976).

    Google Scholar 

  9. Rogers, M. F. et al. Pediatrics 79, 1008–1014 (1987).

    CAS  PubMed  Google Scholar 

  10. AIDS Reporting System, (Center for Disease Control).

  11. Mortality and Morbitity Weekly Report (Center for Disease Control) 34, 373–375 (1985).

  12. Thomas, P., O'Donnell, R., Williams, R. & Chiasson, M. A. New Engl. J. Med. 319, 374 (1988).

    CAS  PubMed  Google Scholar 

  13. Mortality and Morbitity Weekly Report (Center for Disease Control) 36, (suppl S-6), 1–48 (1987).

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Authors and Affiliations

  1. New York State Department of Health, Wadsworth Center for Laboratories and Research, P.O. Box 509, Albany, New York, 12201, USA

    I. Auger & C. E. Lawrence

  2. New York City Department of Health, AIDS Surveillance, Box 44, 125 Worth St, New York, New York, 10013, USA

    P. Thomas & R. Williams

  3. Department of Biostatistics, Harvard School of Public Health, 677 Huntington Ave, Boston, Massachusetts, 02115, USA

    V. De Gruttola & D. Moore

  4. New York State Department of Health, Bureau of Communicable Disease Control, Albany, New York, 12237, USA

    D. Morse & B. Truman

Authors
  1. I. Auger
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  2. P. Thomas
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  3. V. De Gruttola
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  4. D. Morse
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  5. D. Moore
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  6. R. Williams
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  7. B. Truman
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  8. C. E. Lawrence
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Auger, I., Thomas, P., De Gruttola, V. et al. Incubation periods for paediatric AIDS patients. Nature 336, 575–577 (1988). https://doi.org/10.1038/336575a0

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