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Expression of the c-fms proto-oncogene during human monocytic differentiation

Nature volume 316, pages 64–66 (1985)Cite this article

Abstract

The McDonough strain of the feline sarcoma virus contains a transforming gene (v-fms) which contains partial nucleotide homology with proto-oncogenes encoding tyrosine kinases1–4. One of the v-fms-encoded products, gp140fms, is a cell surface trans-membrane glycoprotein that may function as a growth factor receptor5,6. Although c-fms transcripts have been detected in placental trophoblasts7–10 and normal human bone marrow11, the role of the c-fms gene product is unknown. We now report that induction of monocytic, but not granulocytic, differentiation of human HL-60 leukaemic cells is associated with expression of c-fms, preceded by that of c-myc and c-fos. Because c-fms transcripts are also detectable in peripheral blood monocytes and in blasts from certain patients with myelomonocytic leukaemia, the c-fms gene product may play a role in monocytic differentiation.

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Authors and Affiliations

  1. Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Eric Sariban, Thomas Mitchell & Donald Kufe

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  1. Eric Sariban
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  2. Thomas Mitchell
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  3. Donald Kufe
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Sariban, E., Mitchell, T. & Kufe, D. Expression of the c-fms proto-oncogene during human monocytic differentiation. Nature 316, 64–66 (1985). https://doi.org/10.1038/316064a0

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