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Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas

Nature volume 303, pages 401–406 (1983)Cite this article

Abstract

Comparative nucleotide sequence analysis of a rearranged c-myc gene in a murine plasmacytoma and c-myc cDNA from normal spleen reveals that chromosomal translocation in the plasmacytoma breaks the c-myc gene within the first exon or intron. In the plasmacytoma truncated c-myc RNAs initiate from newly exposed promoter sites. Nevertheless, the myc polypeptide produced in the plasmacytoma is probably the same as that from the intact c-myc gene because the exon lost by breakage and translocation is non-coding. The second and third exons of the mouse c-myc gene are substantially conserved in the v-myc gene of the avian retrovirus, MC29.

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References

  1. Klein, G. Nature 294, 313–318 (1981).

    Article  ADS  CAS  Google Scholar 

  2. Rowley, J. P. Science 216, 749–751 (1982).

    Article  ADS  CAS  Google Scholar 

  3. Harris, L. J., D'Eustachio, P., Ruddle, F. H. & Marcu, K. B. Proc. natn. Acad. Sci. U.S.A. 79, 6622–6626 (1982).

    Article  ADS  CAS  Google Scholar 

  4. Calame, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6994–6998 (1982).

    Article  ADS  CAS  Google Scholar 

  5. Adams, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6966–6970 (1982).

    Article  ADS  CAS  Google Scholar 

  6. Shen-Ong, G. L. C., Keath, E., Piccoli, S. P. & Cole, M. D. Cell 31, 443–452 (1982).

    Article  CAS  Google Scholar 

  7. Taub, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7837–7841 (1982).

    Article  ADS  CAS  Google Scholar 

  8. Crews, S., Barth, R., Hood, L., Prehn, J. & Calame, K. Science 218, 1319–1321 (1982).

    Article  ADS  CAS  Google Scholar 

  9. Marcu, K. B. et al. Proc. natn. Acad. Sci. U.S.A. 80, 519–523 (1983).

    Article  ADS  CAS  Google Scholar 

  10. Dalla-Favera, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7824–7827 (1982).

    Article  ADS  CAS  Google Scholar 

  11. Neel, B. G., Jhanwar, S. C., Chaganti, R. S. K. & Hayward, W. S. Proc. natn. Acad. Sci. U.S.A. 79, 7842–7846 (1982).

    Article  ADS  CAS  Google Scholar 

  12. deKlein, A. et al. Nature 300, 765–767 (1982).

    Article  ADS  CAS  Google Scholar 

  13. Harris, L. J., Lang, R. B. & Marcu, K. B. Proc. natn. Acad. Sci. U.S.A. 79, 4175–4179 (1982).

    Article  ADS  CAS  Google Scholar 

  14. Kirsch, I. R. et al. Nature 293, 585–587 (1981).

    Article  ADS  CAS  Google Scholar 

  15. Mushinski, J. F., Bauer, S. R., Potter, M. & Reddy, E. P. Proc. natn. Acad. Sci. U.S.A. 80, 1073–1077 (1983).

    Article  ADS  CAS  Google Scholar 

  16. Alitalo, K. et al. Proc. natn. Acad. Sci. U.S.A. 80, 100–104 (1983).

    Article  ADS  CAS  Google Scholar 

  17. Varmus, H. E. Science 216, 812–820 (1982).

    Article  ADS  CAS  Google Scholar 

  18. Klempnauer, K. H., Gonda, T. J. & Bishop, J. M. Cell 31, 453–463 (1982).

    Article  CAS  Google Scholar 

  19. Donner, P., Greiser-Wilke, I. & Moelling, K. Nature 296, 262–266 (1982).

    Article  ADS  CAS  Google Scholar 

  20. Corden, J. et al. Science 209, 1406–1414 (1980).

    Article  ADS  CAS  Google Scholar 

  21. Benoist, C., O'Hare, K., Breathnach, R. & Chambon, P. Nucleic Acids Res. 8, 127–142 (1980).

    Article  CAS  Google Scholar 

  22. Miller, K. G. & Sollner-Webb, B. Cell 27, 165–174 (1981).

    Article  CAS  Google Scholar 

  23. Miesfeld, R., Krystal, M. & Arnheim, N. Nucleic Acids Res. 9, 5931–5907 (1980).

    Google Scholar 

  24. Hamada, H., Petrino, M. G. & Kakunaga, T. Proc. natn. Acad. Sci. U.S.A. 79, 6465–6469 (1982).

    Article  ADS  CAS  Google Scholar 

  25. Vorlickova, M., Kypr, J., Stokrova, S. & Sponar, J. Nucleic Acids Res. 10, 1071–1080 (1982).

    Article  CAS  Google Scholar 

  26. Zimmer, C., Tyman, S., Marck, C. & Guschlbauer, W. Nucleic Acids Res. 10, 1081–1091 (1982).

    Article  CAS  Google Scholar 

  27. Singleton, C. K., Klysik, J. & Wells, R. D. (in preparation).

  28. Westin, E. H. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2490–2494 (1982).

    Article  ADS  CAS  Google Scholar 

  29. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    Article  ADS  CAS  Google Scholar 

  30. Messing, J., Crea, R. & Seeburg, P. H. Nucleic Acids Res. 9, 309–322 (1981).

    Article  CAS  Google Scholar 

  31. Davis, M. M., Kim, S. K. & Hood, L. Science 209, 1360–1365 (1980).

    Article  ADS  CAS  Google Scholar 

  32. Hu, N. T. & Messing, J. Gene 17, 271–277 (1982).

    Article  CAS  Google Scholar 

  33. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  34. Wahl, G. M., Stern, M. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 76, 3683–3687 (1979).

    Article  ADS  CAS  Google Scholar 

  35. Thomas, P. S. Proc. natn. Acad. Sci. U.S.A. 77, 5201–5205 (1980).

    Article  ADS  CAS  Google Scholar 

  36. Casey, J. & Davidson, N. Nucleic Acids Res. 4, 1539–1552 (1977).

    Article  CAS  Google Scholar 

  37. Vogt, V. M. Eur. J. Biochem. 33, 192–200 (1973).

    Article  CAS  Google Scholar 

  38. Adams, J., Gerondakis, S., Webb, E., Corcoran, L. M. & Cory, S. Proc. natn. Acad. Sci. U.S.A. 80, 1982–1986 (1983).

    Article  ADS  CAS  Google Scholar 

  39. Cory, S., Gerondakis, S. & Adams, J. H. Embo J. (in the press).

  40. Watt, R. et al. Nature (in the press).

  41. Colby, W. W., Chen, E. Y., Smith, D. H. & Levinson, A. D. Nature 301, 722–725 (1983).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Biochemistry Department and Molecular Biology Graduate Program, SUNY at Stony Brook, Stony Brook, New York, 11794, USA

    Lawrence W. Stanton & Kenneth B. Marcu

  2. Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, Pennsylvania, 19104, USA

    Rosemary Watt

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  1. Lawrence W. Stanton
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  2. Rosemary Watt
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  3. Kenneth B. Marcu
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Stanton, L., Watt, R. & Marcu, K. Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature 303, 401–406 (1983). https://doi.org/10.1038/303401a0

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  • DOI: https://doi.org/10.1038/303401a0

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