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A molecular map of the immune response region from the major histocompatibility complex of the mouse

Nature volume 300, pages 35–42 (1982)Cite this article

A Publisher Correction to this article was published on 23 May 2024

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Abstract

A stretch of 200 kilobases (kb) of DNA from the I region of the mouse major histocompatibility complex has been cloned and characterized. It contains the genes for the biochemically defined class II proteins Eα, Eβ and Aβ. DNA blot analyses suggest that the I region may contain only 6–8 class II genes. Correlation of our molecular map with the genetic map of the I region confines two of the five I subregions, I–J and I–B, to less than 3.4 kb of DNA at the 3′ end of the Eβ gene where a hotspot for recombination has been observed. Indeed, the I–A and I–E subregions may be contiguous. If so, the I–B and I–J subregions are not encoded in the I region between the I–A and I–E subregions.

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Authors and Affiliations

  1. Division of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Michael Steinmetz, Karyl Minard, Suzanna Horvath & Leroy Hood

  2. Department of Biological Sciences, Stanford University, Stanford, California, 94305, USA

    Janet McNicholas

  3. Departments of Microbiology and Neurology, University of Southern California School of Medicine, Los Angeles, California, 90033, USA

    Jeffrey Srelinger

  4. Department of Microbiology, University of Geneva Medical School, Geneva, Switzerland

    Claire Wake, Eric Long & Bernard Mach

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  1. Michael Steinmetz
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  3. Suzanna Horvath
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Steinmetz, M., Minard, K., Horvath, S. et al. A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature 300, 35–42 (1982). https://doi.org/10.1038/300035a0

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