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A monoclonal antibody defining antigenic determinants on subpopulations of mammalian neurones and Trypanosoma cruzi parasites

Nature volume 296, pages 34–38 (1982)Cite this article

Abstract

An IgM λ class monoclonal antibody raised against membranes from rat dorsal root ganglia defines a novel antigenic determinant expressed by subpopulations of mammalian central and peripheral neurones. In the presence of complement the antibody is cytotoxic to mammalian neurones in vitro. The same antibody labels Trypanosoma cruzi, the protozoan responsible for Chagas' disease. Classes of mammalian neurones and cardiac muscle that are labelled by the antibody are known to degenerate in Chagas' disease. The common neuronal and trypanosomal antigens recognized by the antibody may therefore be important in pathogenic events underlying this disorder.

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Author notes

  1. J. N. Wood

    Present address: Department of Experimental Immunobiology, Wellcome Research Laboratories, Beckenham, Kent, BR3 3BS, UK

  2. T. M. Jessell

    Present address: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, 02115, USA

  3. M. Yamamoto

    Present address: College of Medical Technology, University of Tsukuba, Niihari-gun, Ibaraki, Japan

Authors and Affiliations

  1. Departments of Immunology and Pharmacology, St George's Hospital Medical School, London, SW17 0RE, UK

    J. N. Wood, L. Hudson, T. M. Jessell & M. Yamamoto

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  4. M. Yamamoto
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Wood, J., Hudson, L., Jessell, T. et al. A monoclonal antibody defining antigenic determinants on subpopulations of mammalian neurones and Trypanosoma cruzi parasites. Nature 296, 34–38 (1982). https://doi.org/10.1038/296034a0

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