Abstract
A recent nationwide survey of the lymphocyte subpopulations of leukaemia and lymphoma in Japan has disclosed a high incidence of adult T-cell leukaemia (ATL)1. One of the striking features of this disease is the clustering of patients in the southwestern part of Japan1,2. We have established a continuous culture line of leukaemic T cells from a patient with ATL3,4. This cell line, MT-1, was found to carry type C virus particles and ATL-associated antigens (ATLA) which specifically reacted with sera from all ATL patients and about 25% of healthy adults in the endemic area5. We report here that by co-culture of ATL cells from a female patient and normal human cord leukocytes from a male infant, a T-cell line of cord leukocyte origin was established. Numerous type C virus particles as well as ATLA were detected in this cell line.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
The T- and B-cell Malignancy Study Group Jap. J. clin. Oncol. 11, 15–38 (1981).
Uchiyama, T., Yodoi, J., Sagawa, K., Takatsuki, K. & Uchino, H. Blood 50, 481–492 (1977).
Miyoshi, I. et al. Jap. J. clin. Oncol. 9, Suppl, 485–494 (1979).
Miyoshi, I. et al. Gann 71, 155–156 (1980).
Hinuma, Y. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Miyoshi, I., Kubonishi, I., Yoshimoto, S. & Shiraishi, Y. Gann (in the press).
Barbacid, M., Bolognesi, D. & Aaronson, S. A. Proc. natn. Acad. Sci. U.S.A. 77, 1617–1621 (1980).
Poiesz, B. J. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7415–7419 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Miyoshi, I., Kubonishi, I., Yoshimoto, S. et al. Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature 294, 770–771 (1981). https://doi.org/10.1038/294770a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/294770a0
