Abstract
THE responsiveness of a target organ to insulin is evidently subject to regulation. This phenomenon is best demonstrated by the presence in man and animals of insulin-resistant states1–4. Since these states are usually accompanied by elevations in plasma insulin levels, a role for insulin in the modulation of insulin-sensitivity of target organs has been proposed4–6. Here we present direct evidence for ‘self-modulation’ by insulin of the insulin-sensitivity of adipocytes. The change in insulin-sensitivity occurs in conjunction with an alteration in the capability of the cells to bind insulin. However, it is not clear if this alteration contributes to the insulin resistance since the change in binding was detected only at relatively high concentrations of 125I-labelled insulin.
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LIVINGSTON, J., PURVIS, B. & LOCKWOOD, D. Insulin-dependent regulation of the insulin-sensitivity of adipocytes. Nature 273, 394–396 (1978). https://doi.org/10.1038/273394a0
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DOI: https://doi.org/10.1038/273394a0
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