Abstract
THE mouse mutant Jimpy is considered to be a model for certain human diseases in which the development of myelin is abnormal1,2. Biochemical studies of Jimpy have shown that myelin components are reduced but no specific abnormality in the assembly of myelin has been detected2–4. This electron microscopic study describes for the first time abnormalities in astroglia of Jimpy optic nerve that are likely to inhibit the development of oligodendroglial cells and myelination.
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SKOFF, R. Myelin deficit in the Jimpy mouse may be due to cellular abnormalities in astroglia. Nature 264, 560–562 (1976). https://doi.org/10.1038/264560a0
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DOI: https://doi.org/10.1038/264560a0
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