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Quantitative evaluation of concanavalin A receptor site distributions on the surfaces of specific populations of embryonic cells

Abstract

MORPHOGENESIS and malignant invasion seem to be dependent on cellular migration and changes in cellular adhesiveness1–3. Plant lectins such as concanavalin A (con A) have been extensively used to study the nature and distribution of lectin receptor sites on the surfaces of normal, embryonic and tumour cells. These sites may be involved in controlling cellular migration and adhesiveness2,4,5.

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References

  1. Townes, P. L., and Holtfreter, J., J. exp. Zool., 128, 53–120 (1955).

    Article  Google Scholar 

  2. Moscona, A. A., Science, 171, 905–907 (1971).

    Article  ADS  CAS  Google Scholar 

  3. Nicolson, G. L., Winkelhake, J. L., Nature, 255, 230–232 (1975).

    Article  ADS  CAS  Google Scholar 

  4. Friberg, S. J., Cochran, A. J., and Golub, S. H., Nature new Biol., 232, 121–122 (1971).

    Article  CAS  Google Scholar 

  5. Oppenheimer, S. B., Edidin, M., Orr, C. W., and Roseman, S., Proc. natn. Acad. Sci. U.S.A., 63, 1395–1402 (1969).

    Article  ADS  CAS  Google Scholar 

  6. Kleinschuster, S. J., and Moscona, A. A., Expl Cell Res., 70, 397–410 (1972).

    Article  CAS  Google Scholar 

  7. Krach, S. W., Green, A., Nicolson, G. L., and Oppenheimer, S. B., Expl Cell Res., 84, 191–198 (1974).

    Article  CAS  Google Scholar 

  8. Sivak, A., and Wolman, S. R., In Vitro, 8, 1–6 (1972).

    Article  CAS  Google Scholar 

  9. Robertson, M., and Oppenheimer, S. B., Expl Cell Res., 91, 263–268 (1975).

    Article  Google Scholar 

  10. Roberson, M., Neri, A., and Oppenheimer, S. B., Science (in the press).

  11. Noonan, K. D., and Burger, M. M., J. Cell Biol., 59, 134 (1973).

    Article  CAS  Google Scholar 

  12. Nicolson, G. L., Concanavalin A (edit. by Chowdhury, T. K., and Weiss, A. K.), 153–172 (1975).

    Book  Google Scholar 

  13. Rosenblith, J. Z., Ukena, T. E., Yin, H., Berlin, R. D., and Karnovsky, M. J., Proc. natn. Acad. Sci. U.S.A., 70, 1625–1629 (1973).

    Article  ADS  CAS  Google Scholar 

  14. Nicolson, G. L., and Yanagimachi, R., Science, 184, 1294–1296 (1974).

    Article  ADS  CAS  Google Scholar 

  15. Inbar, M., Huet, C., Oseroff, A. R., Ben-Bassat, H., and Sachs, L., Biochim. biophys. Acta, 311, 594–599 (1973).

    Article  CAS  Google Scholar 

  16. Levin, A., Killander, D., Klein, E., Nordenskjöld, B., and Inoue, M., Ann. N.Y. Acad. Sci., 177, 481–489 (1971).

    Article  ADS  CAS  Google Scholar 

  17. Neri, A., Roberson, M., Oppenheimer, S. B., in Concanavalin A as a Tool (edit. by Bittiger, H., and Schnebli, H. P.) (in the press).

Download references

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NERI, A., ROBERSON, M., CONNOLLY, D. et al. Quantitative evaluation of concanavalin A receptor site distributions on the surfaces of specific populations of embryonic cells. Nature 258, 342–344 (1975). https://doi.org/10.1038/258342a0

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