Abstract
IN mice1 paraaminobenzoic acid(PABA) in the diet of the host is necessary for the growth of blood infections of Plasmodium berghei. The area of the parasite metabolism in which PABA is involved is believed to be closely associated with the point of action of certain antimalarial drugs including pyrimethamine, proguanil and the sulphonamides. Several drugs of this group are antagonized by PABA2. The effect of PABA on the antimalarial action of chloroquine has received little attention as chloroquine does not seem to act directly on the pathways of PABA metabolism. Kirakosyan3, however, has shown that chloroquine is more effective against a sensitive strain of P. berghei berghei in mice when PABA is absent from the diet of the host.
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References
Jacobs, R. L., Exp. Parasitol., 15, 213 (1964).
Aviado, M. D., Exp. Parasitol., 25, 399 (1969).
Kirakosyan, S. D., Medskaya Parazit., 39, 662 (1970).
Warhurst, D. C., and Killick-Kendrick, R., Nature, 213, 1048 (1967).
Resistance of Malaria Parasites to Drugs, Tech. Rep. Ser., World Health Org., 296 (1965).
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CARTER, R. Effect of PABA on Chloroquine Resistance in Plasmodium berghei yoelii. Nature 238, 98–99 (1972). https://doi.org/10.1038/238098b0
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DOI: https://doi.org/10.1038/238098b0
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