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Induction of Specific Autoimmune Response to Leukaemic Cells in Human Leukaemia Patient by Chemically Tagged Normal “O” Group White Blood Cells

Nature volume 232, pages 198–199 (1971)Cite this article

Abstract

WHITE blood cells from normal healthy O group people, when suitably tagged with chemicals such as 1-fluoro-2,4-dinitrobenzene (FDNB), can be used as antigens to stimulate the production of antibodies to human leukaemic cells in rabbits and horse1,2. We have shown that chemically tagged normal O group white blood cells can be used successfully to induce a specific autoimmune response to leukaemic cells in human leukaemic patients.

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References

  1. Sahasrabudhe, M. B., Indian J. Cancer, 5, 217 (1968).

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  2. Sahasrabudhe, M. B., Prema, S., Madyastha, K. R., Gollerkeri, M. P., and Rao, S. S., Nature, 232, 197 (1971).

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  3. Berenbaum, M. C., in Immunity, Cancer and Chemotherapy (edit. by Mihich, E.), 217 (Academic Press, 1967).

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Author information

Authors and Affiliations

  1. Cancer Research Institute, Parel, Bombay, 12

    M. B. SAHASRABUDHE, K. R. MADYASTHA & S. PREMA

  2. Grant Medical College, and J. J. Group of Hospitals, Byculla, Bombay, 8

    R. D. LELE

  3. Tata Memorial Hospital, Parel, Bombay, 12

    M. P. GOLLERKERI

  4. Haffkine Institute, Parel, Bombay, 12

    S. S. RAO

Authors
  1. M. B. SAHASRABUDHE
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  2. K. R. MADYASTHA
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  3. S. PREMA
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  4. R. D. LELE
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  5. M. P. GOLLERKERI
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  6. S. S. RAO
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SAHASRABUDHE, M., MADYASTHA, K., PREMA, S. et al. Induction of Specific Autoimmune Response to Leukaemic Cells in Human Leukaemia Patient by Chemically Tagged Normal “O” Group White Blood Cells. Nature 232, 198–199 (1971). https://doi.org/10.1038/232198a0

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  • DOI: https://doi.org/10.1038/232198a0

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