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Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation

Nature volume 228, pages 864–866 (1970)Cite this article

Abstract

CALCIUM is thought to be required for the binding of adrenal corticotrophic hormone (ACTH) to its cellular receptor1–5: in its absence, ACTH fails to stimulate steroidogenesis in the adrenal or lipolysis in adipose tissue1,2,6,7. The actions of other lipolytic hormones such as adrenaline and glucagon do not require calcium1–3. On the other hand, high calcium concentrations (>1 mM) inhibit the activation of adenyl cyclase by ACTH in subcellular particles from adipose and adrenal tissue8,9. The sites of these effects of calcium have not been unequivocally located.

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Authors and Affiliations

  1. Diabetes Section, Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, and Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    ROBERT J. LEFKOWITZ, JESSE ROTH & IRA PASTAN

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  1. ROBERT J. LEFKOWITZ
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  3. IRA PASTAN
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LEFKOWITZ, R., ROTH, J. & PASTAN, I. Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation. Nature 228, 864–866 (1970). https://doi.org/10.1038/228864a0

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