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Xg Locus : Failure to detect Inactivation in Females with Chronic Myelocytic Leukaemia

Nature volume 226, pages 367–368 (1970)Cite this article

Abstract

THE inactive-X hypothesis states that only one of the two X chromosomes in each somatic cell of adult mammalian females is genetically active. The initial event in early embryogenesis which determines whether the paternal or the maternal X chromosome will remain active in any given cell is presumably random; once made, the choice is fixed for that cell and for all its descendants1–4. Although this type of inactivation has been demonstrated in man for a number of X-linked loci5, it is not known whether the entire X chromosome is inactivated.

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Authors and Affiliations

  1. Departments of Medicine and Genetics, University of Washington, Seattle, Washington, 98105

    P. J. FIALKOW

  2. Department of Genetics, Instituto Nacional de la Nutricion, Mexico, DF

    R. LISKER

  3. King County Central Blood Bank and Department of Medicine, University of Washington, Seattle, Washington, 98105

    ELOISE R. GIBLETT

  4. Department of Genetics, Instituto Nacional de la Nutricion, Mexico, DF

    C. ZAVALA

Authors
  1. P. J. FIALKOW
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  2. R. LISKER
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  3. ELOISE R. GIBLETT
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  4. C. ZAVALA
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FIALKOW, P., LISKER, R., GIBLETT, E. et al. Xg Locus : Failure to detect Inactivation in Females with Chronic Myelocytic Leukaemia. Nature 226, 367–368 (1970). https://doi.org/10.1038/226367a0

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