Abstract
IN animal cells the synthesis of ribosomal RNA follows a definite molecular pattern. The two ribosomal RNA subunits, 28S and 18S RNA, are synthesized in the nucleolus as a large 45S molecule1,2. The latter is rapidly cleaved into an 18S molecule and into a 32S molecule. The 18S molecule reaches the cytoplasm immediately. The 32S molecule is converted into a 28S molecule in the nucleolus before reaching the cytoplasm3.
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References
Scherrer, K., Latham, H., amd Darnell, J. E., Proc. US Nat. Acad. Sci., 49, 240 (1963).
Girard, M., Penman, S., and Darnell, J. E., Proc. US Nat. Acad. Sci., 51, 205 (1964).
Penman, S., J. Mol. Biol., 17, 117 (1966).
Greenberg, H., and Penman, S., J. Mol. Biol., 21, 527 (1966).
Zimmerman, E. F., and Holler, R. W., J. Mol. Biol., 23, 149 (1967).
Wagner, E., Penman, S., and Ingram, V., J. Mol. Biol., 29, 371 (1967).
Weinberg, R. A., Leoning, U., Willems, M., and Penman, S., Proc. US Nat. Acad. Sci., 58, 1088 (1967).
Jeantur, P., Amaldi, F., and Attardi, G., J. Mol. Biol., 33, 757 (1968).
Torelli, U., Henry, P. H., and Weissman, S. M., J. Clin. Inv., 47, 1083 (1968).
Scherrer, K., and Darnell, J. E., Biochem. Biophys. Res. Commun., 7, 486 (1962).
Kirby, K. S., Biochem. J., 96, 266 (1965).
Schneider, W. C., J. Biol. Chem., 161, 293 (1945).
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TORELLI, U., TORELLI, G., ANDREOLI, A. et al. Partial Failure of Methylation and Cleavage of 45S RNA in the Blast Cells of Acute Leukaemia. Nature 226, 1163–1165 (1970). https://doi.org/10.1038/2261163a0
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DOI: https://doi.org/10.1038/2261163a0
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