Abstract
ALTHOUGH the presence of defective mutants has been demonstrated in several animal virus systems1–3 the isolation in a pure form of corresponding virions or viral nucleic acid molecules has not proved generally possible so far. It is important, however, for oncogenic virus systems to isolate such mutants to test the hypothesis that defective viruses, similar to or identical with those already recognized, are active in initiating oncogenic processes.
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THORNE, H., EVANS, J. & WARDEN, D. Detection of Biologically Defective Molecules in Component I of Polyoma Virus DNA. Nature 219, 728–730 (1968). https://doi.org/10.1038/219728a0
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DOI: https://doi.org/10.1038/219728a0
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