Abstract
IT has been shown that all biosynthetic reactions involved in the formation of ribonucleic acids (RNA), proteins and phospholipids, become accelerated in rapidly proliferating tissues. This requires, however, the presence of related precursors; in the case of an increased synthesis of RNA, the presence of pyrimidine bases and ribose. Beaconsfield et al.1 demonstrated the existence of a direct correlation between the extent of RNA synthesis and ribose formation by way of the oxidative pentose phosphate cycle. Similarly, an increase of RNA synthesis must be accompanied by an increase in the synthesis of pyrimidine bases. The first step in the pyrimidine synthesis is the transformation of the carbamoyl group from carbamoyl phosphate to L-aspartic acid, forming ureidosuccinic acid. This reaction is catalysed by the irreversibly acting aspartate trans-carbamylase (ATC).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Beaconsfield, P., Ginsburg, J., and Kosinski, Z., Nature, 205, 50 (1965).
Calva, E., and Cohen, P. P., Cancer Res., 19, 679 (1959).
Calva, E., Lowenstein, J. M., and Cohen, P. P., Cancer Res., 19, 101 (1959).
Kim, S., and Cohen, P. P., Arch. Biochem. Biophys., 109, 421 (1965).
Huggins, Ch., Grand, L. C., and Brillantes, F. P., Nature, 189, 204 (1961).
Engelhart, K., and Gericke, D., Z. Krebsforschg., 66, 316 (1964).
Heise, E., and Görlich, M., Brit. J. Cancer, 20, 539 (1966).
Koritz, S. B., and Cohen, P. P., J. Biol. Chem., 209, 145 (1945).
Bergmeyer, H. U., and Bernt, E., Methoden der enzymatischen Analyse, 837 (Verlag Chemie Weinheim/Bergstrabe, 1962).
Monod, J., Changeux, J. P., and Jacob, F., J. Mol. Biol., 6, 306 (1963).
Koshland, D. E., Science, 142, 1533 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GÖRLICH, M., HEISE, E. Activity of Aspartate Transcarbamylase in Mammary Tumours induced by 7,12-Dimethyl-benzanthracene in the Rat. Nature 213, 934–935 (1967). https://doi.org/10.1038/213934a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/213934a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.