Abstract
THE origin of the proteins in amniotic fluid is not known with any certainty. Previous evidence, obtained from investigations with electrophoretic techniques1,2 and labelled proteins3, suggests that they are obtained from the maternal circulation by filtration through the foetal membranes. The fact that human placental lactogen (HPL) is found in appreciable amounts in normal amniotic fluid and maternal serum, while it cannot be demonstrated in cord blood4, raises the question of whether this protein hormone originates from its maternal or the foetal circulation. This question is important if the endocrine activity of the protein is to be explained.
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References
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Dancis, J., Lind, J., and Vara, P., in The Placenta and Foetal Membranes, 185, edit. by Villee, C. A. (Williams and Wilkins, Baltimore, 1960).
Tallberg, Th., Ruoslahti, E., and Ehnholm, C., Ann. Med. Exp. Fenn., 43, 67 (1965).
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RUOSLAHTI, E., TALLBERG, T. & SEPPÄLÄ, M. Origin of Proteins in Amniotic Fluid. Nature 212, 841 (1966). https://doi.org/10.1038/212841a0
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DOI: https://doi.org/10.1038/212841a0
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