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Microsomal Incorporation of N-Acetyl-D-galactosamine into Blood Group Substance

Abstract

SOLUBLE blood group A and H substances from hog gastric mucosa consist of a protein ‘backbone’ to which numerous oligosaccharide units are attached1,2. These oligosaccharide units are supposed to consist of a chain of D-galactose and N-acetyl-D-hexosamines to which L-fucose residues are laterally linked3–5. Group A substance is considered to differ from group H substance only by an additional α-N-acetylgalactosamine residue at the non-reducing end of the sugar chains. In fact, substances showing H specificity can be obtained from A substances by treatment with α-N-acetylgalactosaminidases6,7.

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TUPPY, H., STAUDENBAUER, W. Microsomal Incorporation of N-Acetyl-D-galactosamine into Blood Group Substance. Nature 210, 316–317 (1966). https://doi.org/10.1038/210316a0

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