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Synaptic Contacts on Axons in the Cerebral Cortex

Abstract

AXO-AXONAL contacts have been described in various areas of the nervous system, including the retina1, spinal cord2, lateral geniculate nucleus3, olfactory bulb4, superior colliculus5 and the vertical lobes of Octopus6. In the spinal cord these junctions have been postulated as a basis for presynaptic inhibition2,7. In addition, axonal endings of basket cells have been described forming synapses with the initial segment of Purkinje cell axons8,9, and physiological evidence for inhibition is found in this area10. Until now, axo-axonal contacts have not been seen in the cerebral cortex.

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WESTRUM, L. Synaptic Contacts on Axons in the Cerebral Cortex. Nature 210, 1289–1290 (1966). https://doi.org/10.1038/2101289a0

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