Abstract
THE effectiveness of the chelating agent triethylenetetramine hexaacetic acid (TTHA) in reducing deposition of cerium-144 in the rat has been reported in a recent publication by Catsch and Schindewolf-Jordan1. The successful removal of cerium-144 from bone reported by these workers suggested the use of this new chelating agent in current investigations of plutonium therapy now in progress in our laboratory. The purpose of this communication is to report preliminary results with TTHA administered to rats containing deposited plutonium and to compare these results with the results of similar treatment with diethylenetriamine pentaacetic acid (DTPA), the present agent of choice for the removal of internally deposited plutonium2.
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References
Catsch, A., and Schindewolf-Jordan, D., Nature, 191, 715 (1961).
Norwood, W. D., J. Occupational Med., 2, 371 (1960).
Foreman, H., and Magee, M., LAMS-2445, 54 (1959).
Smith, V. H., Document HW-59500, 63 (1959).
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BALLOU, J. Removal of Deposited Plutonium by Triethylenetetramine Hexaacetic Acid. Nature 193, 1303–1304 (1962). https://doi.org/10.1038/1931303a0
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DOI: https://doi.org/10.1038/1931303a0
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