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Fate maps old and new

Nature Cell Biology volume 1, pages E103–E109 (1999)Cite this article

Abstract

Fate mapping was once the province of classical experimental embryologists. Now a battery of new and sophisticated methods can be used to trace where cells go and what they do in embryos. Here we use examples from gastrulating fish and amphibian embryos and from the chick limb bud and central nervous system to show how this information has contributed to our understanding of developmental processes. This knowledge will become increasingly important in interpreting the complex patterns of gene expression that are being discovered during development, as well as in understanding the effects of genetic manipulations and in directing experimental interventions.

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Figure 1: Fate maps of early Xenopus embryos.
Figure 2: Fate in the chick wing bud, mapped using lipophilic membrane dyes.
Figure 3: Clonal analysis reveals lineage-restricted compartments in flies and chicks.

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Authors and Affiliations

  1. Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, , UK

    Jonathan D.W. Clarke

  2. Department of Anatomy and Physiology, The Wellcome Trust Building, University of Dundee, Dundee, DD1 5EH, , UK

    Cheryll Tickle

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  1. Jonathan D.W. Clarke
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  2. Cheryll Tickle
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Correspondence to Cheryll Tickle.

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Clarke, J., Tickle, C. Fate maps old and new. Nat Cell Biol 1, E103–E109 (1999). https://doi.org/10.1038/12105

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