In retinitis pigmentosa, rod and cone photoreceptors die. Although rods die as a consequence of rod-specific genetic mutations, there is no clear explanation for the progressive loss of cones. A new study in this issue suggests that changes in the insulin/mTOR pathway and cell starvation can partially account for cone death in this disease.
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Bovolenta, P., Cisneros, E. Retinitis pigmentosa: cone photoreceptors starving to death. Nat Neurosci 12, 5–6 (2009). https://doi.org/10.1038/nn0109-5
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DOI: https://doi.org/10.1038/nn0109-5
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