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CLC-3 spices up GABAergic synaptic vesicles

Nature Neuroscience volume 14, pages 405–407 (2011)Cite this article

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How does chloride enter synaptic vesicle, and is it required for neurotransmitter uptake? A new study finds that the chloride transporter CLC-3 is needed for both acidification and transmitter loading of GABAergic synaptic vesicles.

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Figure 1: Two different models explaining the mechanism of GABA loading by synaptic vesicles.

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Author information

Authors and Affiliations

  1. Gudrun Ahnert-Hilger is at AG Functional Cell Biology, Institute for Integrative Neuroanatomy, Charité Universitätsmedizin Berlin, Berlin, Germany.,

    Gudrun Ahnert-Hilger

  2. Reinhard Jahn is in the Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.,

    Reinhard Jahn

Authors
  1. Gudrun Ahnert-Hilger
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  2. Reinhard Jahn
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Correspondence to Reinhard Jahn.

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The authors declare no competing financial interests.

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Ahnert-Hilger, G., Jahn, R. CLC-3 spices up GABAergic synaptic vesicles. Nat Neurosci 14, 405–407 (2011). https://doi.org/10.1038/nn.2786

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