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Actin dynamics: re-drawing the map

The microtubule-associated proteins MAP2 and tau are important for regulating microtubule dynamics and bundling, but can also bind to actin filaments. It seems, however, that only MAP2 can bind directly to actin filaments and, curiously, the actin-binding domain is situated within the microtubule-binding domain.

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Figure 1: MAP2c, but not tau, can bind actin filaments.
Figure 2: The actin-filament-binding domain of MAP2c is necessary for process initiation.

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Gordon-Weeks, P. Actin dynamics: re-drawing the map. Nat Cell Biol 6, 390–391 (2004). https://doi.org/10.1038/ncb0504-390

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