Daily remodelling of histone proteins underlies interactions between circadian clock genes and metabolic genes. This regulatory mechanism could be widespread, affecting other physiological processes.
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The author has been a consultant and has received an honorarium and/or grant support from the following companies with an interest in sleep/circadian rhythms: Merck; Astra-Zeneca; Servier; Sanofi-Aventis, Resporonics; and Johnson & Johnson. He is also chief executive of (and holds equity in) a small company, NuNetix Inc., that works with pharmaceutical companies to test their compounds for effects on sleep and/or circadian rhythms.
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Turek, F. Tips from the tip of the iceberg. Nature 456, 881–883 (2008). https://doi.org/10.1038/456881a
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DOI: https://doi.org/10.1038/456881a