Abstract
Lung cancer is now the number one cause of cancer death for both men and women. An age-adjusted analysis over the past 25 years shows that in women specifically, lung cancer incidence is on the rise. It is estimated that 10–20 genetic events including the alteration of oncogenes and tumor suppressor genes will have occurred by the time a lung tumor becomes clinically evident. In an effort to identify regions containing novel cancer genes, chromosome 18p11, a band not previously implicated in disease, was examined for loss of heterozygosity (LOH). In this study, 50 matched normal and NSCLC tumor samples were examined using six 18p11 and one 18q12.3 PCR-based polymorphic markers. In addition, LOH was examined in 29 glioblastoma pairs and 14 paired breast carcinomas. This analysis has revealed potentially two regions of LOH in 18p11 in up to 38% of the tumor samples examined. The regions of LOH identified included a 2 cm area between markers D18S59 and D18S476, and a more proximal, 25 cm region of intermediate frequency between D18S452 and D18S453. These results provide evidence for the presence of one or more potential tumor suppressor genes on the short arm of chromosome 18 which may be involved in NSCLC, brain tumors and possibly breast carcinomas as well.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tran, Y., Benbatoul, K., Gorse, K. et al. Novel regions of allelic deletion on chromosome 18p in tumors of the lung, brain and breast. Oncogene 17, 3499–3505 (1998). https://doi.org/10.1038/sj.onc.1202258
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1202258
Keywords
This article is cited by
-
Aberrant expression of the candidate tumor suppressor gene DAL-1 due to hypermethylation in gastric cancer
Scientific Reports (2016)
-
Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer
Breast Cancer (2012)
-
Loss of expression of the differentially expressed in adenocarcinoma of the lung (DAL-1) protein is associated with metastasis of non-small cell lung carcinoma cells
Tumor Biology (2012)
-
Loss, mutation and deregulation of L3MBTL4 in breast cancers
Molecular Cancer (2010)
-
The CASPR2 cell adhesion molecule functions as a tumor suppressor gene in glioma
Oncogene (2010)