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Dietary fat and fat types as early determinants of childhood obesity: a reappraisal

International Journal of Obesity volume 30, pages S50–S57 (2006)Cite this article

Abstract

Background:

The growing prevalence of childhood overweight and obesity has renewed interest in determining the influence of the maternal and infant diet on the risk of developing excess fat mass later in life.

Approach:

Review of available human and animal data reporting the effects of dietary fat and fat types early in life on adipose development.

Results:

Rodent studies tend to show that maternal high-fat feeding during pregnancy and lactation results in increased adiposity of the offspring. Nevertheless, today there is a lack of population-based studies investigating this potential detrimental effect of maternal high-fat intake. Most epidemiological studies, performed so far, do not find any association between the level of dietary fat intake of infants and children and body weight and/or fatness. Regarding fat types exposure to high levels of dietary n-6 fatty acids during gestation and post-natal life, has been shown to promote obesity in mice. Nevertheless, other rodent studies do not demonstrate such an effect.

Conclusion:

There is no evidence supporting a restriction of fat intake during the first two post-natal years but the potential detrimental effects of maternal high-fat intake during gestation should be further investigated. The role of dietary fat types as early determinants of childhood obesity has so far been poorly studied. Robust evidence to support the adipogenic effects of n-6 fatty acids enriched-diets is currently lacking but this hypothesis is of importance and should be further evaluated in different animal models as well as in longitudinal human studies.

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References

  1. Milner JA, Allison RG . The role of dietary fat in child nutrition and development: summary of an ASNS workshop. American Society for Nutritional Sciences. J Nutr 1999; 129: 2094–2105.

    Article  CAS  Google Scholar 

  2. Kuzawa CW . Adipose tissue in human infancy and childhood: an evolutionary. Am J Phys Anthropol 1998; 27: 177–209.

    Article  Google Scholar 

  3. Widdowson EM . Chemical composition of newly born mammals. Nature 1950; 166: 626–628.

    Article  CAS  Google Scholar 

  4. Lewis D, Bertrand H, Masoro E, McGill H, Carey K, McMahan CA . Preweaning nutrition and fat development in baboons. J Nutr 1983; 113: 2253–2259.

    Article  CAS  Google Scholar 

  5. Fomon S, Haschke F, Ziegler E, Nelson SE . Body composition of reference children from birth to age 10 years. Am J Clin Nutr 1982; 35: 1169–1175.

    Article  CAS  Google Scholar 

  6. Davies P, Day J, Lucas A . Energy expenditure in early infancy and later body fatness. Int J Obes 1991; 15: 727–731.

    CAS  Google Scholar 

  7. Poissonnet CM, Burdi AR, Garn SM . The chronology of adipose tissue appearance and distribution in the human fetus. Early Hum Dev 1984; 10: 1–11.

    Article  CAS  Google Scholar 

  8. Burdi AR, Poissonnet CM, Garn SM, Lavelle M, Sabet MD, Bridges P . Adipose tissue growth patterns during human gestation: a histometric comparison of buccal and gluteal fat depots. Int J Obes 1985; 9: 247–256.

    CAS  Google Scholar 

  9. Haggarty P . Placental regulation of fatty acid delivery and its effect on fetal growth--a review. Placenta 2002; 23: S28–38.

    Article  Google Scholar 

  10. Herrera E, Amusquivar E . Lipid metabolism in the fetus and the newborn. Diabet Metab Res Rev 2000; 16: 202–210.

    Article  CAS  Google Scholar 

  11. Knittle JL, Ginsberg-Fellner F, Brown RE . Adipose tissue development in man. Am J Clin Nutr 1977; 30: 762–766.

    Article  CAS  Google Scholar 

  12. Hager A, Sjostrm L, Arvidsson B, Bjorntorp P, Smith U . Body fat and adipose tissue cellularity in infants: a longitudinal study. Metabolism 1977; 26: 607–614.

    Article  CAS  Google Scholar 

  13. Hirsch J, Fried SK, Edens NK, Leibel RL . The fat cell. Med Clin North Am 1989; 73: 83–96.

    Article  CAS  Google Scholar 

  14. Knittle JL, Timmers K, Ginsberg-Fellner F, Brown RE, Katz DP . The growth of adipose tissue in children and adolescents. Cross-sectional and longitudinal studies of adipose cell number and size. J Clin Invest 1979; 63: 239–246.

    Article  CAS  Google Scholar 

  15. Roche AF . The adipocyte-number hypothesis. Child Dev 1981; 52: 31–43.

    Article  CAS  Google Scholar 

  16. Stettler N, Zemel BS, Kumanyika S, Stallings VA . Infant weight gain and childhood overweight status in a multicenter, cohort study. Pediatrics 2002; 109: 194–199.

    Article  Google Scholar 

  17. Stettler N, Stallings VA, Troxel AB, Zhao J, Schinnar R, Nelson SE et al. Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula. Circulation 2005; 111: 1897–1903.

    Article  Google Scholar 

  18. FAO/WHO. Fats and oils in human nutrition. Report of a joint expert consultation. Report 57. Rome, 1994; 1–115.

  19. AAPC. American Academy of Pediatrics Committee on Nutrition: Statement on cholesterol. Pediatrics 1992; 90: 469–473.

  20. Williams CL, Bollella M, Boccia L, Spark A . Dietary fat and children health (nutrition and the life cycle). Nutr Today 1998; 33: 144–155.

    Article  Google Scholar 

  21. Martorell R, Stein AD, Schroeder DG . Early nutrition and later adiposity. J Nutr 2001; 131: 874S–880S.

    Article  CAS  Google Scholar 

  22. Remacle C, Bieswal F, Reusens B . Programming of obesity and cardiovascular disease. Int J Obes Relat Metab Disord 2004; 28: S46–53.

    Article  Google Scholar 

  23. Hausman DB, McCloskey HM, Martin RJ . Maternal dietary fat type influences the growth and fatty acid composition of newborn and weanling rats. J Nutr 1991; 121: 1917–1923.

    Article  CAS  Google Scholar 

  24. Guo F, Jen KL . High-fat feeding during pregnancy and lactation affects offspring metabolism in rats. Physiol Behav 1995; 57: 681–686.

    Article  CAS  Google Scholar 

  25. Khan IY, Dekou V, Douglas G, Jenson R, Hanson MA, Poston L et al. A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol 2005; 288: R127–R133 (E-pub 12 August 2004).

    Article  CAS  Google Scholar 

  26. Martin RJ, Herbein JH . Effect of a high fat diet on body composition, cellularity, and enzyme levels during early development of the rat. Proc Soc Exp Biol Med 1980; 164: 341–346.

    Article  CAS  Google Scholar 

  27. Buckley AJ, Keseru B, Briody J, Thompson M, Ozanne SE, Thompson CH . Altered body composition and metabolism in the male offspring of high fat-fed rats. Metabolism 2005; 54: 500–507.

    Article  CAS  Google Scholar 

  28. Mitoulas LR, Kent JC, Cox DB, Owens RA, Sherriff JL, Hartmann PE . Variation in fat, lactose and protein in human milk over 24 h and throughout the first year of lactation. Br J Nutr 2002; 88: 29–37.

    Article  CAS  Google Scholar 

  29. Michaelsen KF, Larsen PS, Thomsen BL, Samuelson G . The Copenhagen Cohort Study on Infant Nutrition and Growth: breast-milk intake, human milk macronutrient content, and influencing factors. Am J Clin Nutr 1994; 59: 600–611.

    Article  CAS  Google Scholar 

  30. Hall WG . Weaning and growth of artificially reared rats. Science 1975; 190: 1313–1315.

    Article  CAS  Google Scholar 

  31. Srinivasan M, Laychock SG, Hill DJ, Patel MS . Neonatal nutrition: metabolic programming of pancreatic islets and obesity. Exp Biol Med (Maywood) 2003; 228: 15–23.

    Article  CAS  Google Scholar 

  32. Michaelsen KF . Nutrition and growth during infancy. The Copenhagen Cohort Study. Acta Paediatr Suppl 1997; 420: 1–36.

    Article  CAS  Google Scholar 

  33. West DB, York B . Dietary fat, genetic predisposition, and obesity: lessons from animal models. Am J Clin Nutr 1998; 67: 505S–512S.

    Article  CAS  Google Scholar 

  34. Woods SC, Seeley RJ, Rushing PA, D'Alessio D, Tso P . A controlled high-fat diet induces an obese syndrome in rats. J Nutr 2003; 133: 1081–1087.

    Article  CAS  Google Scholar 

  35. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Institute of Medicine of the National Academies Ed., The National Academic Press: Washington DC, 2002/2005; 422–541.

  36. Apports nutritionnels conseillés pour population francaise 3éme edn. TEC & DOC, Paris., 2001; 63–82.

  37. Valuers de reference pour les nutritionels. 1ére edn. Association Suisse pour 1'alimentation. Umschau Braus GmbH, editeurs, Francfort. 2002; 45–60.

  38. Salem Jr N, Wegher B, Mena P, Uauy R . Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proc Natl Acad Sci USA 1996; 93: 49–54.

    Article  CAS  Google Scholar 

  39. Carnielli VP, Wattimena DJ, Luijendijk IH, Boerlage A, Degenhart HJ, Sauer PJ . The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. Pediatr Res 1996; 40: 169–174.

    Article  CAS  Google Scholar 

  40. Uauy R, Castillo C . Lipid requirements of infants: implications for nutrient composition of fortified complementary foods. J Nutr 2003; 133: 2962S–2972S.

    Article  Google Scholar 

  41. Smith WL . The eicosanoids and their biochemical mechanisms of action. Biochem J 1989; 259: 315–324.

    Article  CAS  Google Scholar 

  42. Vassaux G, Far DF, Gaillard D, Ailhaud G, Negrel R . Inhibition of prostacyclin-induced Ca2+ mobilization by phorbol esters in Ob1771 preadipocytes. Prostaglandins 1993; 46: 441–451.

    Article  CAS  Google Scholar 

  43. Reginato MJ, Krakow SL, Bailey ST, Lazar MA . Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma. J Biol Chem 1998; 273: 1855–1858.

    Article  CAS  Google Scholar 

  44. Massiera F, Saint-Marc P, Seydoux J, Murata T, Kobayashi T, Narumiya S et al. Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res 2003; 44: 271–279 (E-pub 4 November 2002).

    Article  CAS  Google Scholar 

  45. Ailhaud G, Guesnet P . Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion. Obes Rev 2004; 5: 21–26.

    Article  CAS  Google Scholar 

  46. Korotkova M, Gabrielsson B, Lonn M, Hanson LA, Strandvik B . Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet. J Lipid Res 2002; 43: 1743–1749.

    Article  CAS  Google Scholar 

  47. Bourre JM, Dumont O, Durand G . Does an increase in dietary linoleic acid modify tissue concentrations of cervonic acid and consequently alter alpha-linolenic requirements? Minimal requirement of linoleic acid in adult rats. Biochem Mol Biol Int 1996; 39: 607–619.

    CAS  Google Scholar 

  48. Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF . Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. Pediatr Res 2005; 58: 235–242 (E-pub 8 July 2005).

    Article  CAS  Google Scholar 

  49. Groh-Wargo S, Jacobs J, Auestad N, O'Connor DL, Moore JJ, Lerner E . Body composition in preterm infants who are fed long-chain polyunsaturated fatty acids: a prospective, randomized, controlled trial. Pediatr Res 2005; 57: 712–718 (E-pub 17 February 2005).

    Article  CAS  Google Scholar 

  50. Holloway BR, Davidson RG, Freeman S, Wheeler H, Stribling D . Post-natal development of interscapular (brown) adipose tissue in the guinea pig: effect of environmental temperature. Int J Obes 1984; 8: 295–303.

    CAS  Google Scholar 

  51. Stone KJ, Willis AL, Hart WM, Kirtland SJ, Kernoff PB, McNicol GP . The metabolism of dihomo-gamma-linolenic acid in man. Lipids 1979; 14: 174–180.

    Article  CAS  Google Scholar 

  52. Huang YS, Horrobin DF, Manku MS, Mitchell J . Effect of dietary alpha- and gamma-linolenic acid on tissue fatty acids in guinea pigs. Proc Soc Exp Biol Med 1985; 178: 46–49.

    Article  CAS  Google Scholar 

  53. Fletcher B, Berra K, Ades P, Braun LT, Burke LE, Durstine JL et al. Managing abnormal blood lipids: a collaborative approach. Circulation 2005; 112: 3184–3209.

    Article  Google Scholar 

  54. Pediatrics. Aao. Committee on Nutrition. Cholesterol in childhood. Pediatrics 1998; 101: 141–147.

  55. Aggett PJ, Haschke F, Heine W, Hernell O, Koletzko B, Lafeber H et al. Committee report: childhood diet and prevention of coronary heart disease. ESPGAN Committee on Nutrition. European Society of Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr 1994; 19: 261–269.

    CAS  Google Scholar 

  56. Nielsen GA, Thomsen BL, Michaelsen KF . Influence of breastfeeding and complementary food on growth between 5 and 10 months. Acta Paediatr 1998; 87: 911–917.

    Article  CAS  Google Scholar 

  57. Stunkard AJ, Berkowitz RI, Schoeller D, Maislin G, Stallings VA . Predictors of body size in the first 2 y of life: a high-risk study of human obesity. Int J Obes Relat Metab Disord 2004; 28: 503–513.

    Article  CAS  Google Scholar 

  58. Butte NF, Wong WW, Hopkinson JM, Smith EO, Ellis KJ . Infant feeding mode affects early growth and body composition. Pediatrics 2000; 106: 1355–1366.

    Article  CAS  Google Scholar 

  59. Scaglioni S, Agostoni C, Notaris RD, Radaelli G, Radice N, Valenti M et al. Early macronutrient intake and overweight at five years of age. Int J Obes Relat Metab Disord 2000; 24: 777–781.

    Article  CAS  Google Scholar 

  60. Dorosty AR, Emmett PM, Cowin S, Reilly JJ . Factors associated with early adiposity rebound. ALSPAC Study Team. Pediatrics 2000; 105: 1115–1118.

    Article  CAS  Google Scholar 

  61. Nicklas TA, Farris RP, Smoak CG, Franc GC, Srinivasan SR, Webber LS et al. Dietary factors relate to cardiovascular risk factors in early life. Bogalusa Heart Study. Arteriosclerosis 1988; 8: 193–199.

    Article  CAS  Google Scholar 

  62. Boulton TJ, Magarey AM . Effects of differences in dietary fat on growth, energy and nutrient intake from infancy to eight years of age. Acta Paediatr 1995; 84: 146–150.

    Article  CAS  Google Scholar 

  63. Rolland-Cachera MF, Deheeger M, Akrout M, Bellisle F . Influence of macronutrients on adiposity development: a follow up study of nutrition and growth from 10 months to 8 years of age. Int J Obes Relat Metab Disord 1995; 19: 573–578.

    CAS  Google Scholar 

  64. Davies PS . Diet composition and body mass index in pre-school children. Eur J Clin Nutr 1997; 51: 443–448.

    Article  CAS  Google Scholar 

  65. Atkin LM, Davies PS . Diet composition and body composition in preschool children. Am J Clin Nutr 2000; 72: 15–21.

    Article  CAS  Google Scholar 

  66. Skinner JD, Bounds W, Carruth BR, Morris M, Ziegler P . Predictors of children's body mass index: a longitudinal study of diet and growth in children aged 2-8 y. Int J Obes Relat Metab Disord 2004; 28: 476–482.

    Article  CAS  Google Scholar 

  67. Klesges RC, Klesges LM, Eck LH, Shelton ML . A longitudinal analysis of accelerated weight gain in preschool children. Pediatrics 1995; 95: 126–130.

    CAS  Google Scholar 

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Acknowledgements

The authors are grateful to Dr K Acheson for critically reading the manuscript.

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Authors and Affiliations

  1. Department of Nutrition & Health, Nestlé Research Center, Vers-chez-les-Blanc CP 44, 1000, Lausanne, 26, Switzerland

    K Macé, Y Shahkhalili, O Aprikian & S Stan

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Macé, K., Shahkhalili, Y., Aprikian, O. et al. Dietary fat and fat types as early determinants of childhood obesity: a reappraisal. Int J Obes 30 (Suppl 4), S50–S57 (2006). https://doi.org/10.1038/sj.ijo.0803519

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