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Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree

International Journal of Obesity volume 27, pages 347–354 (2003)Cite this article

Abstract

OBJECTIVE: To determine the prevalence of elevated C-reactive protein (CRP) in the Sandy Lake Oji-Cree, an aboriginal community residing in the Sioux Lookout zone of Northwestern Ontario, Canada, and to determine the associations of obesity and diabetes with CRP in a community with a very high prevalence of type II diabetes.

DESIGN: We surveyed 512 community members aged 18?y and older to determine the prevalence and the determinants of elevated CRP in Sandy Lake.

MEASUREMENTS:Clinical variables, indices of obesity and serum concentrations of CRP, insulin, serum amyloid A (SAA) and interleukin-6 (IL-6).

RESULTS: The prevalence of CRP ≥3.8?mg/l was significantly higher in women than in men (51% vs. 32%, P<0.0001). Regression analysis determined that body mass index and IL-6 were independent determinants of CRP concentration in women and waist circumference and IL-6 were independent determinants of CRP concentration in men. Diabetes was associated with elevated CRP in both sexes, but was only a moderate strong determinant in CRP concentration in multivariate regression analysis.

CONCLUSIONS: The prevalence of elevated CRP in this aboriginal community is remarkably high. These data further demonstrate that the association between CRP and specific indices of obesity and metabolism vary according to gender and glycemic status.

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Acknowledgements

The authors would like to acknowledge the following groups and individuals, whose cooperation was essential in the design and implementation of this project: the chief, council and community members of Sandy Lake First Nation; the Sandy Lake community surveyors (Louisa Kakegamic, Tina Noon, Madeliene Kakegamic, and Elda Anishinabie, Annette Rae, Connie Kakegamic, Mary Mamakeesic); the Sandy Lake nurses; the staff of the University of Toronto Sioux Lookout Programme; the Department of Clinical Epidemiology of the Samuel Lunenfeld Research Institute; Dr Alexander Logan, Annette Barnie and Sasan Mohammadi-Khah. This work was supported by grants from the National Institutes of Health (91-DK-01 and 1-R21-DK-44597-01), and the Ontario Ministry of Health (#04307) and the Canadian Diabetes Association.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    P W Connelly

  2. Department of Medicine, University of Toronto, Toronto, ON, Canada

    P W Connelly, A J Hanley & B Zinman

  3. Department of Biochemistry, University of Toronto, Toronto, ON, Canada

    P W Connelly

  4. J. Alick Little Lipid Research Laboratory, St Michael's Hospital, Toronto, ON, Canada

    P W Connelly

  5. Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON, Canada

    A J Hanley & B Zinman

  6. Centre for Studies in Family Medicine, University of Western Ontario, London, ON, Canada

    S B Harris

  7. Robarts Research Institute, London, ON, Canada

    R A Hegele

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Correspondence to P W Connelly.

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Connelly, P., Hanley, A., Harris, S. et al. Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree. Int J Obes 27, 347–354 (2003). https://doi.org/10.1038/sj.ijo.0802239

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